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Bio-O-Pump: a novel portable microfluidic device driven by osmotic pressure

机译:Bio-O-Pump:一种由渗透压驱动的新型便携式微流体装置

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摘要

The concepts of lab on a chip, miniaturised fluidic systems, and biochips entail the use of a fluid to perform analogue or digital operations. The temporal and spatial fluidic drive and control in microfluidic systems usually involves a complex pump, tubing, and connection system. Reducing the number of external components is crucial for use by scientists without an engineering background. In this paper, we present a novel pump-free device that uses an osmotic-pressure-driven flow to control and modulate fluid flow in microfluidic networks. The flow rate was regulated by controlling the osmotic area and the concentration of the draw solution, which comprised an easily accessible solution of electrolytes such as commercial sterile saline buffer and sodium chloride solution. The Bio-O-Pump can continuously generate liquid movement up to a flow rate of 4.88 mL h(-1) over 1 h. This research also presents a single cell trapping application for biomedical uses.
机译:芯片实验室,小型化流体系统和生物芯片的概念要求使用流体来执行模拟或数字操作。微流体系统中的时空流体驱动和控制通常涉及复杂的泵,管道和连接系统。对于没有工程背景的科学家来说,减少外部组件的数量至关重要。在本文中,我们提出了一种新型的无泵设备,该设备使用渗透压驱动的流量来控制和调节微流体网络中的流体流量。通过控制渗透面积和汲取溶液的浓度来调节流速,汲取溶液包括容易获得的电解质溶液,例如商业无菌盐水缓冲液和氯化钠溶液。 Bio-O-Pump可以在1小时内连续产生液体运动,流速达到4.88 mL h(-1)。这项研究还提出了一种用于生物医学用途的单细胞捕获应用。

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