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首页> 外文期刊>Sensors and Actuators >Reflectometric detection of influenza virus in human saliva using nanoimprint lithography-based flexible two-dimensional photonic crystal biosensor
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Reflectometric detection of influenza virus in human saliva using nanoimprint lithography-based flexible two-dimensional photonic crystal biosensor

机译：基于纳米压印光刻的柔性二维光子晶体生物传感器的反射法检测人唾液中的流感病毒

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摘要

Protecting the human body from viral infections is extremely important for maintaining human health. To prevent viral infections, early diagnosis is important. Moreover, the diagnosis must also be non-invasive and non-painful. Hence, for development of novel analytical systems for protecting from viral infections, non-invasive biosensing devices with high sensitivity and high throughput are effective analytical systems that can be conveniently used to make a diagnosis. For establishment of novel analytical systems, photonic crystal (PC) can be used to observe nanometer-sized periodic structures, and their structural color can be used to realize on-site non-invasive biosensor. In this study, we have demonstrated the reflectometric detection of influenza virus in human saliva using antibody-immobilized flexible nanoimprint lithography (NIL)-based two-dimensional (2D)-PC biosensor. As a result, using antibody-immobilized 2D-PC biosensor, reflection intensity change which related with influenza virus concentrations could be observed. In addition, we could detect the influenza virions present in human saliva (detection limit: 1 ng mL~(-1)). Our approach provides versatile analytical systems for the establishment of novel rapid diagnostic systems of serious viral diseases.
机译：保护人体免受病毒感染对于维持人体健康极为重要。为了预防病毒感染，早期诊断很重要。此外，诊断还必须是非侵入性和非痛苦的。因此，为了开发用于保护免受病毒感染的新型分析系统，具有高灵敏度和高通量的无创生物传感装置是可以方便地用于诊断的有效分析系统。为了建立新颖的分析系统，可以使用光子晶体（PC）观察纳米级的周期性结构，并使用其结构颜色来实现现场无创生物传感器。在这项研究中，我们已经证明了使用抗体固定的基于柔性纳米压印技术（NIL）的二维（2D）-PC生物传感器对人唾液中流感病毒的反射检测。结果，使用固定有抗体的2D-PC生物传感器，可以观察到与流感病毒浓度有关的反射强度变化。此外，我们可以检测到人类唾液中存在的流感病毒粒子（检测限：1 ng mL〜（-1））。我们的方法为建立用于严重病毒性疾病的新型快速诊断系统提供了通用的分析系统。

著录项

  • 来源
    《Sensors and Actuators》 |2010年第1期|P.269-276|共8页
  • 作者

    Tatsuro Endo; Satoshi Ozawa; Norimichi Okuda; Yasuko Yanagida; Satoru Tanaka; Takeshi Hatsuzawa;

  • 作者单位

    Department of Mechano-Micro Engineering, Interdisciplinary Graduate School of Science and Engineering, Tokyo Institute of Technology, 4259 Nagatsuta-cho, Midori-ku, Yokohama 226-8502,Japan Precision and Intelligence Laboratory, Tokyo Institute of Technology, 4259 Nagatsuta-cho, Midori-ku, Yokohama 226-8503, Japan;

    rnSCIVAX Corporation, Science Park East 502,3-2-1 Sakado, Takatsu-ku, Kawasaki-shi, Kanagawa 213-0012, Japan;

    rnSCIVAX Corporation, Science Park East 502,3-2-1 Sakado, Takatsu-ku, Kawasaki-shi, Kanagawa 213-0012, Japan;

    rnDepartment of Mechano-Micro Engineering, Interdisciplinary Graduate School of Science and Engineering, Tokyo Institute of Technology, 4259 Nagatsuta-cho, Midori-ku, Yokohama 226-8502,Japan Precision and Intelligence Laboratory, Tokyo Institute of Technology, 4259 Nagatsuta-cho, Midori-ku, Yokohama 226-8503, Japan;

    rnSCIVAX Corporation, Science Park East 502,3-2-1 Sakado, Takatsu-ku, Kawasaki-shi, Kanagawa 213-0012, Japan;

    rnDepartment of Mechano-Micro Engineering, Interdisciplinary Graduate School of Science and Engineering, Tokyo Institute of Technology, 4259 Nagatsuta-cho, Midori-ku, Yokohama 226-8502,Japan Precision and Intelligence Laboratory, Tokyo Institute of Technology, 4259 Nagatsuta-cho, Midori-ku, Yokohama 226-8503, Japan;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    biosensor; nanoimprint lithography (NIL); photonic crystal (PC); influenza virus; salivary monitoring; reflectometric detection;

    机译：生物传感器纳米压印光刻（NIL）;光子晶体（PC）;流感病毒唾液监测;反射检测;

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