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首页> 外文期刊>Speculations on Science and Technology >Mitotic and amitotic cell replication in malignant melanoma: the role of subdivisional cell replication
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Mitotic and amitotic cell replication in malignant melanoma: the role of subdivisional cell replication

机译：恶性黑色素瘤中的有丝分裂和无丝分裂细胞复制：细分细胞复制的作用

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It is widely assumed that significant mitotic activity is typical of malignant melanoma and many believe that significant mitotic activity is essential for this diagnosis. We have studied mitotic activity in 205 malignant melanomas and have found that mitotic activity is often minimal or absent, event in malignant melanomas which have recurred or metastasized. Based on our previous work suggesting that new cells can form from nucleoli via nucleolar stalks, we also studied nucleolar stalks in our cases. These were present in greater numbers than mitoses and help explain the anomaly of infre- quent mitoses in a highly malignant neoplasm.
机译：普遍认为，有丝分裂活动是恶性黑色素瘤的典型特征，许多人认为，有丝分裂活动对该诊断至关重要。我们研究了205例恶性黑色素瘤的有丝分裂活性，发现在复发或转移的恶性黑色素瘤中，有丝分裂活性通常很少或没有。根据我们以前的工作表明新的细胞可以通过核仁柄从核仁中形成，我们还研究了本例中的核仁柄。这些细胞的数量要比有丝分裂的多，这有助于解释高度恶性肿瘤中很少有丝分裂的异常。

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