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Assessing repeatability and reproducibility using hierarchical modeling: a case-study of distortion product otoacoustic emissions

机译：使用分层模型评估可重复性和可再现性：失真产物耳声发射的案例研究

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摘要

We present how the repeatability and reproducibility of a measurement device can be estimated from a suitably denned hierarchical linear model. The methodology is illustrated using a collection of eight data sets which consist of the distortion product otoacoustic emission recordings collected from both ears of ten young Sprague-Dawley rats at different frequencies under eight different recording conditions. We formulate a model which extends the commonly used one-way random effects model (5) to account for an experimental setup that is more elaborated than the ones traditionally used in interlaboratory experiments. The fitted model is easily interpretable and furnishes as a by-product the frequencies at which the highest response level is achieved under the eight recording conditions. These values together with the repeatability and reproducibility limits of the protocols are crucial in contributing to the enhancement of the research capabilities on the possible causes of hearing impairment.
机译：我们介绍了如何从适当定义的分层线性模型中估算测量设备的可重复性和可重复性。使用八个数据集的集合来说明该方法，该数据集由在八种不同记录条件下以不同频率从十只Sprague-Dawley幼鼠的两只耳朵的畸变产物耳声发射记录组成。我们制定了一个模型，该模型扩展了常用的单向随机效应模型（5），以说明比实验室间实验中传统使用的实验设置更为精细的实验设置。拟合的模型易于解释，并作为副产品提供了在八种记录条件下达到最高响应级别的频率。这些值以及协议的可重复性和可再现性限制对于增强听力障碍可能原因的研究能力至关重要。

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