Search for novel substances with nootropic activity in the series of N-substituted azacrown-ethers

Karaseva T.L.; Basopk S.S.; Lukyanenko N.G.

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Search for novel substances with nootropic activity in the series of N-substituted azacrown-ethers

机译：在一系列N-取代的氮杂冠醚中寻找具有促智活性的新物质

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Derivatives of azacrown-ethers containing in their side chain pharmacophore groups were synthesized and their pharmacological activity were studied. It was shown that compounds investigated to possess the wide spectrum of psychotropic activity. The compound containing in its structure GABA residue was found to possess the most high nootropic activity. This substance has substantial advantages by its antiamnestic and antihypoxic effects over gammalone, piracetam, phenibut, oxybutirate sodium -drugs, that widely used in medical practice.

机译：合成了在其侧链药效基团中包含的氮杂冠醚的衍生物，并研究了它们的药理活性。结果表明，所研究的化合物具有广泛的精神活性。发现在其结构中含有GABA残基的化合物具有最高的促智活性。该物质相对于广泛用于医学实践的γ-马洛酮，吡乙酰胺，苯乙丁酯，羟丁酸钠药物具有显着的优势，具有抗记忆和抗氧作用。

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《Украинский химический журнал》 |1999年第10期|p.104-110|共7页
作者
Karaseva T.L.; Basopk S.S.; Lukyanenko N.G.;
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收录信息美国《科学引文索引》(SCI);
原文格式 PDF
正文语种 rus
中图分类化学;
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Search for novel substances with nootropic activity in the series of N-substituted azacrown-ethers

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