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首页> 外文期刊>Veterinary Research Communications >Pharmacokinetics of Enrofloxacin and Its Metabolite Ciprofloxacin after Intramuscular Administration of Enrofloxacin in Goats
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Pharmacokinetics of Enrofloxacin and Its Metabolite Ciprofloxacin after Intramuscular Administration of Enrofloxacin in Goats

机译：山羊中肌内注射恩诺沙星后恩诺沙星及其代谢产物环丙沙星的药代动力学

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The pharmacokinetics of enrofloxacin and its active metabolite ciprofloxacin were investigated in goats after a single intramuscular administration of enrofloxacin at 2.5 mg/kg body weight. The plasma concentrations of enrofloxacin and ciprofloxacin were determined simultaneously by a HPLC method. The peak concentrations (C max) of enrofloxacin (1.13 μg/ml) and ciprofloxacin (0.24 μg/ml) were observed at 0.8 and 1.2 h, respectively. The elimination half-life (t 1/2β), volume of distribution (V d(area)), total body clearance (ClB) and mean residence time (MRT) of enrofloxacin were 0.74 h, 1.42 L/kg, 1329 ml/h per kg and 1.54 h, respectively. The t 1/2β, area under the plasma concentration–time curve (AUC) and the MRT of ciprofloxacin were 1.38 h, 0.74 μg h/ml and 2.73 h, respectively. The metabolic conversion of enrofloxacin to ciprofloxacin was appreciable (36%) and the sum of the plasma concentrations of enrofloxacin and ciprofloxacin was maintained at or above 0.1 μg/ml for up to 4 h. Enrofloxacin appears to be useful for the treatment of goat diseases associated with pathogens sensitive to this drug.
机译：在以2.5 mg / kg体重单次肌内注射恩诺沙星后，在山羊中研究了恩诺沙星及其活性代谢产物环丙沙星的药代动力学。恩诺沙星和环丙沙星的血浆浓度通过HPLC法同时测定。分别在0.8和1.2h观察到恩诺沙星（1.13μg/ ml）和环丙沙星（0.24μg/ ml）的峰值浓度（C max）。恩诺沙星的消除半衰期（t 1 /2β），分布体积（V d（面积）），总体内清除率（ClB ）和平均停留时间（MRT）分别为0.74 h，1.42 L / kg，1329 ml / h / kg和1.54 h。血浆浓度-时间曲线（AUC）下的t 1 /2β面积，环丙沙星的MRT分别为1.38 h，0.74μgh / ml和2.73 h。恩诺沙星向环丙沙星的代谢转化率可观（36％），并且恩诺沙星和环丙沙星的血浆浓度之和保持在0.1μg/ ml或更高，持续4小时。恩诺沙星似乎可用于治疗与对该药物敏感的病原体有关的山羊疾病。

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