Effect of Viral Double-Stranded RNA on Mammalian Cells in Culture: Cytotoxicity Under Conditions Preventing Viral Replication and Protein Synthesis

B. Cordell-Stewart; Milton W. Taylor

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Effect of Viral Double-Stranded RNA on Mammalian Cells in Culture: Cytotoxicity Under Conditions Preventing Viral Replication and Protein Synthesis

机译：病毒双链RNA对培养中哺乳动物细胞的影响：治疗病毒复制和蛋白质合成条件下的细胞毒性

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Noninfectious bovine enterovirus double-stranded RNA induces cytopathic effects when added to mammalian cells in culture. This is demonstrated by 51Cr release from prelabeled murine lymphoma cells and trypan blue uptake. Also, the induction of cell death by this viral RNA occurs in the presence of inhibitors of protein synthesis (cycloheximide and puromycin). The possible role and mechanism of viral, double-stranded RNA as a cytopathic agent in virally infected cells are discussed.

机译：非染色牛肠道病毒双链RNA在添加到培养物中加入哺乳动物的细胞时诱导细胞病变效果。通过预先标记的鼠淋巴瘤细胞和台盼蓝吸收来证明这一点是由 51 cr释放的。此外，这种病毒RNA对细胞死亡的诱导发生在蛋白质合成的抑制剂（环己酰亚胺和嘌呤菌素）的存在下。讨论了病毒，双链RNA作为病毒性感染细胞中的细胞病剂的可能作用和机制。

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《Journal of Virology》 |1973年第2期|共7页
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B. Cordell-Stewart; Milton W. Taylor;
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收录信息美国《科学引文索引》(SCI);
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1. Effect of Viral Double-Stranded RNA on Mammalian Cells in Culture: Cytotoxicity Under Conditions Preventing Viral Replication and Protein Synthesis [J] . B. Cordell-Stewart, Milton W. Taylor Journal of Virology . 1973,第2期

机译：病毒双链RNA对培养中哺乳动物细胞的影响：治疗病毒复制和蛋白质合成条件下的细胞毒性
2. Effect of Viral Double-Stranded RNA on Mammalian Cells in Culture: Cytotoxicity Under Conditions Preventing Viral Replication and Protein Synthesis [J] . B. Cordell-Stewart, Milton W. Taylor Journal of Virology . 1973,第2期

机译：病毒双链RNA对培养中哺乳动物细胞的影响：治疗病毒复制和蛋白质合成条件下的细胞毒性
3. The viral protein 3CD induces an equilibrium between the viral protein and RNA synthesis in a cell-free system for poliovirus replication. [J] . Verlinden Y, Cuconati A, Wimmer E, Archives of virology . 2002,第4期

机译：在无脊髓灰质炎病毒复制的无细胞系统中，病毒蛋白3CD诱导了病毒蛋白与RNA合成之间的平衡。
4. Non-viral (polymeric) delivery of combinational siRNAs against cell cycle and phosphatase proteins to prevent metastasis in breast cancer [C] . Manoj Parmar, Remant Bahadur Kc, Robert Maranchuk, World biomaterials congress . 2016

机译：siRNA的非病毒（聚合）递送可抵抗细胞周期和磷酸酶蛋白，从而预防乳腺癌的转移
5. Interactions between Host Cell and Picornavirus Proteins and their Functions in Viral Translation and RNA Replication [D] . Daijogo, Sarah Lynn 2011

机译：宿主细胞和小核糖核酸蛋白之间的相互作用及其在病毒翻译和RNA复制中的功能
6. Effect of Viral Double-Stranded RNA on Mammalian Cells in Culture: Cytotoxicity Under Conditions Preventing Viral Replication and Protein Synthesis [O] . B. Cordell-Stewart, Milton W. Taylor 1973

机译：病毒双链RNA对培养的哺乳动物细胞的影响：防止病毒复制和蛋白质合成的条件下的细胞毒性。
7. Effect of Double-Stranded Viral RNA on Mammalian Cells in Culture [O] . Cordell-Stewart, B., Taylor, Milton W. 1971

机译：双链病毒RNA对培养的哺乳动物细胞的影响

Effect of Viral Double-Stranded RNA on Mammalian Cells in Culture: Cytotoxicity Under Conditions Preventing Viral Replication and Protein Synthesis

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