• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Pharmacoepidemiology and drug safety >Adverse reactions of anti-tuberculosis drugs in hospitalized patients: incidence, severity and risk factors.
【24h】

Adverse reactions of anti-tuberculosis drugs in hospitalized patients: incidence, severity and risk factors.

机译：住院患者抗结核药物的不良反应：发生率，严重性和危险因素。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

BACKGROUND: Tuberculosis (TB) has been a common chronic infectious disease in human communities. Besides disease-related complications, there could be serious adverse reactions due to anti-tuberculosis (anti-TB) drug therapy. OBJECTIVES: To assess the incidence and severity of adverse drug reactions (ADRs) induced by anti-TB drugs. To determine possible covariates associated with detected ADRs. METHODS: All patients with respiratory TB admitted to a teaching hospital who received anti-TB drugs during the research period entered the study and were monitored for ADRs. Socio-demographic and medical history of patients were used as independent covariates. The relationship between independent covariates with frequency and severity of ADRs was analysed using multivariate logistic regression. Preliminary analyses of the Mann-Whitney, Chi-square, Kruskal-Wallis and the Fisher's exact tests were applied to determine factors unlikely associated with the independent variables. RESULTS: Among 204 patients admitted, there were 92 patients (45.1%) with ADRs induced by anti-TB drugs. Patients with a previous history of anti-TB drugs usage (OR = 5.81, 95% confidence interval [95%CI]: 1.31-25.2), patients with a history of drug allergy (OR = 6.68, CI: 1.28-36.2), those from Afghani ethnic (OR = 4.91, 95%CI: 1.28-18.30) as well as smoker patients with concurrent diseases (OR = 19.67, CI: 1.24-341.51) had a higher rate of ADR incidence. Being female (OR = 1.63, 95%CI: 1.96-36.40) and having previous history of ADR (OR = 17.46, 95%CI: 1.96-20.42) were identified as risk factors. CONCLUSION: Anti-TB drugs could cause severe and frequent adverse effects. Females, those with a previous history of ADRs to anti-TB drugs and Afghani patients, should be considered as high-risk groups.
机译：背景：结核病（TB）已成为人类社区常见的慢性传染病。除了与疾病相关的并发症外，抗结核药物还可能导致严重的不良反应。目的：评估抗结核药物引起的药物不良反应（ADR）的发生率和严重程度。确定与检测到的ADR相关的可能协变量。方法：所有在研究期间入院的呼吸道结核病患者在研究期间均接受抗结核药物治疗后进入研究，并进行了ADR监测。患者的社会人口统计学和病史被用作独立协变量。使用多元logistic回归分析独立协变量与ADR的频率和严重性之间的关系。对Mann-Whitney，卡方，Kruskal-Wallis和Fisher的精确检验进行了初步分析，以确定与自变量无关的因素。结果：在204例入院患者中，有92例（45.1％）由抗结核药物引起的ADR。具有抗结核药物使用史的患者（OR = 5.81，95％置信区间[95％CI]：1.31-25.2），具有药物过敏史的患者（OR = 6.68，CI：1.28-36.2），来自阿富汗裔人群（OR = 4.91，95％CI：1.28-18.30）以及吸烟者并发疾病（OR = 19.67，CI：1.24-341.51）的ADR发生率更高。被确定为女性（OR = 1.63，95％CI：1.96-36.40）和以前有ADR病史（OR = 17.46，95％CI：1.96-20.42）是危险因素。结论：抗结核药物可能引起严重而频繁的不良反应。女性，那些曾经有抗结核药物ADR病史的人和阿富汗尼患者，应被视为高危人群。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号