• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Pharmacogenetics >Refining the mouse chromosomal location of Cdm, the major gene associated with susceptibility to cadmium-induced testicular necrosis.
【24h】

Refining the mouse chromosomal location of Cdm, the major gene associated with susceptibility to cadmium-induced testicular necrosis.

机译：完善小鼠Cdm的染色体位置，Cdm是与镉诱发的睾丸坏死易感性相关的主要基因。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Cadmium (Cd++) is a widespread environmental pollutant and classifed as an IARC 'Category I' human carcinogen. Cd++ can also cause severe renal toxicity and may be involved clinically in cardiovascular disease and osteoporosis. Genetic differences in sensitivity to cadmium toxicity have been noted in humans, whereas, among inbred mouse strains, unequivocal genetic data exist. Resistance to cadmium-induced testicular damage was reported in 1973 to be associated with a single major recessive gene, named Cdm, which has now been localized to mouse chromosome (Chr) 3. Using polymorphic microsatellite markers and semiquantitative histological parameters, we have corroborated the original 1973 data concerning mendelian inheritance and have further refined the region containing the Cdm gene from more than 24 cM to 0.64 cM (estimated 40-80 genes). We phenotyped 26 recombinant inbred lines generated from C57BL/6J (B6, resistant) and DBA/2J (D2, sensitive) inbred mice, and determined that the Cdm gene maps between microsatellite markers D3Mit110 and D3Mit255. Although toxicity to numerous heavy metals is well known, virtually no molecular mechanisms have yet been uncovered either in humans or laboratory animals. Identification and characterization of the mouse Cdm gene should enhance our understanding of heavy metal toxicity by identifying and characterizing, for the first time, a major mammalian gene responsible for susceptibility to diseases caused by heavy metal toxicity.
机译：镉（Cd ++）是一种广泛的环境污染物，被归类为IARC“ I类”人类致癌物。 Cd ++也可引起严重的肾脏毒性，并可能在临床上涉及心血管疾病和骨质疏松症。在人类中已经注意到对镉毒性敏感性的遗传差异，而在近交小鼠品系中，存在明确的遗传数据。 1973年报道了对镉诱导的睾丸损伤的抗性与单个主要隐性基因Cdm相关，该基因现已定位于小鼠染色体（Chr）3。使用多态微卫星标记和半定量组织学参数，我们证实了1973年有关孟德尔遗传的原始数据，并进一步将包含Cdm基因的区域从24 cM以上提高到0.64 cM（估计40-80个基因）。我们对由C57BL / 6J（抗B6）和DBA / 2J（D2，敏感）近交小鼠产生的26个重组近交系进行表型鉴定，并确定Cdm基因在微卫星标记D3Mit110和D3Mit255之间进行定位。尽管对多种重金属的毒性是众所周知的，但实际上在人类或实验动物中尚未发现分子机制。小鼠Cdm基因的鉴定和表征应通过首次鉴定和鉴定对重金属毒性引起的疾病易感性的主要哺乳动物基因，增强我们对重金属毒性的了解。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号