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首页> 外文期刊>Pharmacogenetics and genomics >Glutathione S-transferase M1 (GSTM1) genotype but not GSTT1 or MC1R genotype influences erythemal sensitivity to narrow band (TL-01) UVB phototherapy.
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Glutathione S-transferase M1 (GSTM1) genotype but not GSTT1 or MC1R genotype influences erythemal sensitivity to narrow band (TL-01) UVB phototherapy.

机译：谷胱甘肽S-转移酶M1（GSTM1）基因型而非GSTT1或MC1R基因型影响对窄带（TL-01）UVB光疗的红斑敏感性。

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摘要

OBJECTIVES: Although a majority of psoriasis patients respond to treatment with narrow band ultraviolet B radiation (TL-01) phototherapy, it is currently not possible to predict erythemal sensitivity, or to identify treatment responders. A variety of antioxidant enzymes, including the polymorphic glutathione S-transferase GSTM1 and GSTT1 genes, protect the cell from UVR-induced oxidative challenge. GSTM1 and GSTT1 are deleted in approximately 50 and 20% of the Caucasian population, respectively, and GST null genotype has been associated with increased sunburn sensitivity and reduced minimal erythemal dose (MED) after broadband UVR exposure in healthy volunteers and with susceptibility to skin cancer. Another polymorphic determinant of UVR sensitivity is the melanocortin 1 receptor (MC1R), which protects cells from UVR-induced apoptosis and photodamage. Our aim was therefore to investigate whether GST or MC1R genotype influenced erythemal sensitivity to narrow band (TL-01) ultraviolet B radiation phototherapy in patients with psoriasis. METHODS: We used TaqMan quantitative gene copy and allelic discrimination assays to determine GST and MC1R genotypes, and looked for possible associations between genotype and threshold erythemal sensitivity (MED) and treatment outcomes in patients with psoriasis (n=256). RESULTS: We showed that GSTM1 genotype, but not GSTT1 or MC1R genotype influences erythemal sensitivity to TL-01 phototherapy, with a significantly lower MED observed in GSTM1 null individuals [chi(2 d.f.)=8.862, P=0.012]. None of the genotypes studied were associated with TL-01 treatment outcomes or relapse rates. CONCLUSION: GSTM1 genotype may have clinical utilityin the prediction of photosensitivity and/or in identifying patients at increased risk of treatment-related side effects.
机译：目的：尽管大多数牛皮癣患者对窄带紫外线B辐射（TL-01）光疗有反应，但目前尚无法预测红斑敏感性或确定治疗反应者。多种抗氧化剂酶，包括多态性谷胱甘肽S-转移酶GSTM1和GSTT1基因，可以保护细胞免受UVR诱导的氧化挑战。 GSTM1和GSTT1分别在大约50％和20％的白种人人群中缺失，并且GST无效基因型与健康志愿者在宽带UVR暴露后增加的晒斑敏感性和降低的最小红斑剂量（MED）相关，并且易患皮肤癌。紫外线敏感性的另一个多态性决定因素是黑皮质素1受体（MC1R），它可以保护细胞免受紫外线诱导的细胞凋亡和光损伤。因此，我们的目的是研究牛皮癣患者的GST或MC1R基因型是否影响对窄带（TL-01）紫外线B辐射光疗的红斑敏感性。方法：我们使用TaqMan定量基因复制和等位基因鉴别测定法确定GST和MC1R基因型，并寻找基因型和阈值红斑敏感性（MED）与牛皮癣患者（n = 256）的治疗结果之间的可能联系。结果：我们显示，GSTM1基因型影响TL-01光疗的红斑敏感性，而GSTT1或MC1R基因型没有影响，在GSTM1 null个体中观察到的MED显着降低[chi（2 d.f。）= 8.862，P = 0.012]。研究的基因型均与TL-01治疗结果或复发率无关。结论：GSTM1基因型可能在预测光敏性和/或鉴定患者中具有与治疗相关的副作用的风险增加中具有临床实用性。

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