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首页> 外文期刊>Biomaterials >Formation of Propionibacterium acnes biofilms on orthopaedic biomaterials and their susceptibility to antimicrobials.
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Formation of Propionibacterium acnes biofilms on orthopaedic biomaterials and their susceptibility to antimicrobials.

机译：骨科生物材料上痤疮丙酸杆菌生物膜的形成及其对抗菌剂的敏感性。

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Failure to treat and eradicate prosthetic hip infection with systemic antibiotic regimens is usually due to the fact that the infection is associated with biofilm formation and that bacterial cells growing within a biofilm exhibit increased resistance to antimicrobial agents. In this in vitro study, we investigated the susceptibility of prosthetic hip Propionibacterium acnes and Staphylococcus spp. isolates growing within biofilms on polymethylmethacrylate (PMMA) bone cement to a range of antibiotics. All P. acnes isolates in the biofilm mode of growth demonstrated considerably greater resistance to cefamandole, ciprofloxacin and vancomycin. In contrast, only four of the eight P. acnes isolates demonstrated an increase in resistance to gentamicin. All ten Staphylococcus spp. isolates in the biofilm mode of growth exhibited large increases in resistance to gentamicin and cefamandole with eight of the ten isolates also exhibiting an increase in resistance to vancomycin. However, only three of the ten Staphylococcus spp. isolates exhibited an increase in resistance to ciprofloxacin. Biofilms were also formed on three different titanium alloys and on PMMA bone cement using P. acnes, Staphylococcus epidermidis and Staphylococcus aureus strains to determine if the underlying biomaterial surface had an effect on biofilm formation and the antimicrobial susceptibility of the bacteria growing within biofilms. Although differences in the rate at which the three strains adhered to the different biomaterials were apparent, no differences in biofilm antibiotic resistance between the biomaterials were observed. In the light of these results, it is important that the efficacy of other antibiotics against P. acnes and Staphylococcus spp. prosthetic hip isolates growing within biofilms on orthopaedic biomaterials be determined to ensure optimal treatment of orthopaedic implant infection.
机译：用全身性抗生素方案无法治疗和根除假体髋部感染通常是由于以下事实：感染与生物膜形成有关，并且在生物膜内生长的细菌细胞对抗菌剂的抵抗力增强。在这项体外研究中，我们调查了假肢髋臼丙酸杆菌和葡萄球菌的易感性。分离在聚甲基丙烯酸甲酯（PMMA）骨水泥上生物膜内生长的多种抗生素。在生物膜生长模式下所有痤疮丙酸杆菌的分离株均显示出对头孢曼多，环丙沙星和万古霉素的抗性明显增强。相反，八个痤疮丙酸杆菌分离物中只有四个表现出对庆大霉素的抗性增加。全部十个葡萄球菌属。以生物膜生长方式分离的分离株对庆大霉素和头孢曼多的抗性大大提高，十个分离株中的八个也显示出对万古霉素的抗性增强。但是，十个葡萄球菌属中只有三个。分离株表现出对环丙沙星的抗性增加。还使用痤疮丙酸杆菌，表皮葡萄球菌和金黄色葡萄球菌菌株在三种不同的钛合金和PMMA骨水泥上形成生物膜，以确定潜在的生物材料表面是否对生物膜的形成以及生物膜内细菌生长的抗菌敏感性产生影响。尽管三种菌株粘附到不同生物材料上的速率的差异是明显的，但是在生物材料之间未观察到生物膜抗生素抗性的差异。根据这些结果，重要的是其他抗生素对痤疮丙酸杆菌和葡萄球菌属的功效。确定在整形外科生物材料上生物膜内生长的假体髋关节分离物，以确保对整形外科植入物感染进行最佳治疗。

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