Synthesis, characterization and antimalarial activity of new iridium-chloroquine complexes

Navarro M; Pekerar S; Perez HA

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Synthesis, characterization and antimalarial activity of new iridium-chloroquine complexes

机译：新型铱-氯喹配合物的合成，表征和抗疟活性

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Chloroquine base (CQ) reacts with [Ir(COD)Cl](2) and IrCl3 center dot 3H2O to yield of Ir(CQ)Cl(COD) (1) and Ir2Cl6(CQ) center dot 3H2O (2), respectively. Reaction of [Ir(C0D)Cl](2)with CQ in the presence of NH4PF6 leaded to [Ir(CQ)(Solv)(2)]PF6 (3). The three new iridium-CQ complexes were characterized by a combination of elemental analysis, IR and NMR spectroscopies and evaluated in vitro against Plasmodium beghei. Comparison of the IC50 values obtained with the experimental compounds with that determined for chloroquine diphosphate indicated a higher activity for complex 2, while complexes 1 and 3 showed a similar and lower activity, respectively. (c) 2006 Elsevier Ltd. All rights reserved.

机译：氯喹碱（CQ）与[Ir（COD）Cl]（2）和IrCl3中心点3H2O反应，分别生成Ir（CQ）Cl（COD）（1）和Ir2Cl6（CQ）中心点3H2O（2）。 [Ir（C0D）Cl]（2）与NH4在NH4PF6存在下的反应生成[Ir（CQ）（Solv）（2）] PF6（3）。通过元素分析，IR和NMR光谱相结合的方法对这三种新的铱-CQ配合物进行了表征，并在体外针对Besmodium beghei进行了评估。用实验化合物获得的IC50值与测定的二磷酸氯喹的IC50值的比较表明，配合物2的活性较高，而配合物1和3的活性分别相似且较低。（c）2006 Elsevier Ltd.保留所有权利。

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《Polyhedron: The International Journal for Inorganic and Organometallic Chemistry》 |2007年第12期|共5页
作者
Navarro M; Pekerar S; Perez HA;
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正文语种 eng
中图分类化学;
关键词
iridium; chloroquine; Plasmodium berghei; malaria; antimalarial; METAL-BASED CHEMOTHERAPY; ACTIVITY IN-VITRO; TROPICAL DISEASES; PLASMODIUM-FALCIPARUM; RESISTANCE; INVITRO; BERGHEI; PFCRT; VIVO;

机译：铱;氯喹;伯氏疟原虫;疟疾;动物;基于金属的化学疗法;体外活性;热带疾病;恶性疟原虫;抗药性;体内;伯氏;PFCRT;体内;

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1. Synthesis, characterization and antimalarial activity of new iridium-chloroquine complexes [J] . Navarro M, Pekerar S, Perez HA Polyhedron: The International Journal for Inorganic and Organometallic Chemistry . 2007,第12期

机译：新型铱-氯喹配合物的合成，表征和抗疟活性
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Synthesis, characterization and antimalarial activity of new iridium-chloroquine complexes

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