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HPLC-MS/MS analysis of willow bark extracts contained in pharmaceutical preparations

机译：药物制剂中柳树皮提取物的HPLC-MS / MS分析

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摘要

Preparations containing willow bark extract are popular herbal remedies, but they are mostly standardised with respect to only one compound (usually salicin). RP-HPLC using a C18-column eluted with water:methanol:tetrahydrofuran and coupled to electrospray triple-quadrupole MS and MS/MS was used for the characterisation of dried extracts of Salix spp. and for the identification of their constituents. Comparison with reference substances led to the identification of 13 compounds (saligenin, salicylic acid, salicin, isosalicin, picein, salidroside, triandrin, salicoylsalicin, salicortin, isosalipurposide, salipurposide, naringenin-7-O-glucoside and tremulacin). Two pharmaceutical preparations containing willow bark extract, used in clinical trials and labelled Salix daphnoides and S. purpurea x daphnoides extracts, were compared using the described method and exhibited several clear differences, the most prominent of which was the possible presence of picein in the former preparation. The described method may be utilised for the characterisation of herbal medicines in order to ensure comparability of medication in further clinical trials.
机译：含有柳树皮提取物的制剂是流行的草药，但大多数仅针对一种化合物（通常是水杨素）进行了标准化。 RP-HPLC使用C18柱，用水，甲醇：四氢呋喃洗脱，并与电喷雾三重四极杆MS和MS / MS偶联，用于表征柳柳干提取物。并确定其成分。与参考物质的比较导致鉴定出13种化合物（s碱苷元，水杨酸，水杨素，异水杨苷，匹西林，红景天苷，三andrin，水杨酰基水杨素，水杨素，异二十碳五糖苷，沙利浦糖苷，柚皮苷7-O-葡糖苷和维曲拉星）。使用所述方法比较了两种用于临床试验的含柳树皮提取物的药物制剂以及标记的柳柳和紫苏葡萄da提取物，并显示出几个明显的区别，其中最突出的是前者中可能存在的芹菜素。制备。所描述的方法可以用于草药的表征，以确保在进一步的临床试验中药物的可比性。

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