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首页> 外文期刊>Poultry Science >Identification of the heart-type fatty acid-binding protein as a major gene for chicken fatty acid metabolism by Bayesian network analysis
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Identification of the heart-type fatty acid-binding protein as a major gene for chicken fatty acid metabolism by Bayesian network analysis

机译：通过贝叶斯网络分析鉴定心脏型脂肪酸结合蛋白作为鸡脂肪酸代谢的主要基因

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摘要

Twenty genes involved in fatty acid metabolism were studied to reveal their effects on chicken fatness traits. To explore the interactions among these genes and evaluate their effects on fat accumulation in chickens, a Bayesian network of candidate genes in fatty acid metabolism and growth was constructed in terms of these genes' mRNA expression data derived from DNA microarray and the effects of these genes on fatness traits were analyzed. A full-sib family Beijing-You chicken population was raised and sampled for investigating the hepatic mRNA expression and measuring the fatness traits at 5 time points from 42 to 98 d. By using a Bayesian network toolbox, we obtained a Bayesian-directed acyclic network, which has 19 nodes and 28 edges. The results showed that the heart-type fatty acid-binding protein (H-FABP) was the hub of the network with connection to 7 other genes. The hepatic mRNA expression of H-FABP was significantly related to i.m. fat content (r = -0.44, P < 0.05) at 70 d of age. The results indicated that the H-FABP gene plays the most important role among these genes associated with fatty acid metabolism and affects i. m. fat content of chickens.
机译：研究了二十种参与脂肪酸代谢的基因，以揭示它们对鸡肉脂肪性状的影响。为了探索这些基因之间的相互作用并评估它们对鸡脂肪堆积的影响，根据DNA微阵列中这些基因的mRNA表达数据以及这些基因的影响，构建了脂肪酸代谢和生长候选基因的贝叶斯网络。对脂肪性状进行了分析。饲养并在42到98 d的5个时间点取样一个全同胞家庭北京油鸡种群，以调查其肝脏mRNA表达并测量其脂肪性状。通过使用贝叶斯网络工具箱，我们获得了贝叶斯定向的非循环网络，该网络具有19个节点和28个边。结果表明，心脏型脂肪酸结合蛋白（H-FABP）是与其他7个基因连接的网络枢纽。 H-FABP的肝mRNA表达与i.m显着相关。 70 d龄时脂肪含量（r = -0.44，P <0.05）。结果表明，H-FABP基因在这些与脂肪酸代谢有关的基因中起着最重要的作用，并影响i。米鸡的脂肪含量。

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