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首页> 外文期刊>Poultry Science >Enhancement of mucosal immune responses in chickens by oral administration of cysteamine
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Enhancement of mucosal immune responses in chickens by oral administration of cysteamine

机译：口服半胱胺可增强鸡的粘膜免疫反应

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Somatostatin, a tetradecapeptide originally isolated from the hypothalamus, can exert an inhibitory effect on the secretion of growth hormone by the anterior pituitary gland. In addition to endocrine organs, somatostatin is also present in the digestive tract and immune organs. In lymphoid tissues, somatostatin appears to play a role in the modulation of the immune response. Cysteamine (CS) is a sulfhydryl reducing agent that is known as a depletory agent of somatostatin. To evaluate its effects on chicken mucosal immune responses, CS was administrated orally to 1-wk-old broilers (40 mg/kg) that were immunized orally with Newcastle disease attenuated vaccine (NDV). The number of IgA-positive cells and intestinal intraepithelial lymphocytes (iIEL) in duodenum and jejunum were examined at 3-, 5-, and 7-wk posttreatment and immunization. The number of somatostatin-positive cells and relative amounts of somatostatin mRNA were also examined in the duodenum. The number of somatostatin-positive cells in the duodenum was reduced (P < 0.05) after CS treatment. In broilers receiving CS and NDV treatment (CS+NDV) the level of IgA-positive cells and iIEL in the duodenum and jejunum was increased (P < 0.05) at 3 and 5 wk posttreatment. The expression of somatostatin mRNA increased (P < 0.05) compared with that of the control group at 5 wk after immunization in broilers receiving CS+NDV or NDV alone. The results suggest that CS can induce proliferation and differentiation of IgA-positive cells and iIEL in the intestinal mucosa of chickens by reducing the number of somatostatin-positive cells.
机译：生长抑素是一种最初从下丘脑分离的四肽，可以抑制垂体前叶分泌生长激素。除内分泌器官外，生长抑素还存在于消化道和免疫器官中。在淋巴组织中，生长抑素似乎在免疫反应的调节中起作用。半胱胺（CS）是一种巯基还原剂，被称为生长抑素的耗竭剂。为了评估其对鸡粘膜免疫反应的影响，对口服新城疫减毒疫苗（NDV）免疫的1周龄肉鸡（40 mg / kg）口服CS。在3周，5周和7周后和免疫后检查十二指肠和空肠中IgA阳性细胞和肠上皮内淋巴细胞（iIEL）的数量。还在十二指肠检查生长抑素阳性细胞的数量和生长抑素mRNA的相对量。 CS治疗后，十二指肠中生长抑素阳性细胞的数量减少（P <0.05）。在接受CS和NDV处理（CS + NDV）的肉鸡中，在处理后3周和5周时，十二指肠和空肠中IgA阳性细胞和iIEL的水平增加（P <0.05）。单独接种CS + NDV或NDV的肉鸡免疫后5周，生长抑素mRNA表达较对照组增加（P <0.05）。结果表明CS可以通过减少生长抑素阳性细胞的数量来诱导鸡肠道粘膜中IgA阳性细胞和iIEL的增殖和分化。

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