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首页> 外文期刊>Prenatal Diagnosis >Prenatal diagnosis of an exceptional intrauterine herpes simplex type 1 infection.
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Prenatal diagnosis of an exceptional intrauterine herpes simplex type 1 infection.

机译：产前诊断为一种特殊的子宫内单纯疱疹1型感染。

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摘要

OBJECTIVE: To assess ultrasound findings of a fetus with intrauterine growth retardation (IUGR) and skin damage, related to intrauterine herpes simplex virus (HSV) infection. METHODS: A 23-year-old, G1, P0 woman was referred at 23.5 weeks' gestation (WG) for IUGR. The patient had a previous single episode of serotype 1 herpes progenitalis at 11 WG. Ultrasound examination revealed extensive skin changes with no cerebral involvement. The methods employed for evaluation of the disease included maternal serology, amniocentesis and repeated ultrasound examinations. RESULTS: Maternal serology was positive for HSV1 and fetal infection was confirmed via polymerase chain reaction (PCR). At 27 WG, amniotic fluid index decreased and lower limb skin as well as abdominal skin was irregular. Oesophagus was thickened. In contrast, upper limb skin and cranial vault were thin and less visible. IUGR was predominant as regards bone parameters. After termination of pregnancy, the fetus showed macroscopic characteristics of HSV infection. Microscopic examination revealed only placental and skin lesions. CONCLUSIONS: Our report illustrates a rare case of HSV1 intrauterine infection that occurred during the first trimester with bone and cephalic IUGR associated with extensive skin damage, and with no cerebral involvement.
机译：目的：评估与子宫内单纯疱疹病毒（HSV）感染有关的胎儿宫内发育迟缓（IUGR）和皮肤损伤的超声检查结果。方法：一名23岁，G1，P0的妇女在IUGR妊娠23.5周时被转诊。该患者先前曾有一次单发性血清型1型先天性疱疹，发病率为11 WG。超声检查发现皮肤广泛变化，无脑部受累。评价该疾病的方法包括产妇血清学检查，羊膜穿刺术和反复超声检查。结果：母体血清HSV1阳性，并通过聚合酶链反应（PCR）证实了胎儿感染。在27 WG时，羊水指数下降，下肢皮肤和腹部皮肤不规则。食道增厚。相反，上肢皮肤和颅穹顶较薄且较不可见。就骨骼参数而言，IUGR是主要的。终止妊娠后，胎儿表现出HSV感染的宏观特征。镜检仅显示胎盘和皮肤病变。结论：我们的报告说明了在头三个月发生的少见的HSV1宫内感染病例，其骨和头IUGR伴有广泛的皮肤损伤，并且没有大脑受累。

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