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首页> 外文期刊>Prenatal Diagnosis >First trimester markers of preeclampsia in twins: Maternal mean arterial pressure and uterine artery Doppler pulsatility index
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First trimester markers of preeclampsia in twins: Maternal mean arterial pressure and uterine artery Doppler pulsatility index

机译：双胞胎先兆子痫前三个月的标志：母亲平均动脉压和子宫动脉多普勒搏动指数

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Objective: This study aims to evaluate the distribution of mean arterial pressure (MAP) and uterine artery Doppler pulsatility index (PI) in first trimester twins with and without preeclampsia. Method: A total of 147 twins were recruited from a specialist clinic and 110 unaffected singleton pregnancies attending the same institution served as controls. MAP and Doppler PI values were expressed in multiples of the gestation-specific median using published equations. Results: Among the twins, 12 had preeclampsia and two had pregnancy-induced hypertension. Among unaffected pregnancies, there was no significant difference in MAP levels between twins and singletons (P=0.17, Wilcoxon rank sum test, two-tail). However, the Doppler PI levels were highly statistically significantly lower than in singletons (P<0.0005). MAP was unrelated to chorionicity (P=0.46), but there was a statistically significant increase in Doppler PI among monochorionic compared with dichorionic twins (P<0.01). In twins with preeclampsia, MAP was significantly higher than in unaffected twins (P<0.02, one-tail), whereas Doppler PI levels were significantly reduced (P<0.01, two-tail). Conclusion: If first trimester screening for preeclampsia is extended to twins, a different normal median Doppler PI equation will be needed. Contrary to expectations, Doppler PI levels may not be raised in affected twins, although this needs confirmation in a larger study.
机译：目的：本研究旨在评估子痫前期和未子痫前期双胎平均动脉压（MAP）和子宫动脉多普勒脉动指数（PI）的分布。方法：从专科诊所招募了147名双胞胎，并在同一机构就诊的110例未受影响的单胎孕妇作为对照。 MAP和多普勒PI值使用已发表的方程式以特定于妊娠的中位数表示。结果：在双胞胎中，有12例患有先兆子痫，其中2例患有妊娠高血压。在未受影响的怀孕中，双胞胎和单胎之间的MAP水平没有显着差异（P = 0.17，Wilcoxon秩和检验，两尾）。但是，多普勒PI水平在统计学上显着低于单身人士（P <0.0005）。 MAP与绒毛膜性无关（P = 0.46），但是单绒毛膜中的多普勒PI与双绒毛双胞胎相比有统计学意义的增加（P <0.01）。在患有先兆子痫的双胞胎中，MAP显着高于未患病的双胞胎（P <0.02，一个尾巴），而多普勒PI水平显着降低（P <0.01，两个尾巴）。结论：如果早孕子痫前期筛查扩展至双胎，则将需要不同的正常中位多普勒PI方程。与预期相反，患双胞胎的多普勒PI水平可能不会升高，尽管这需要在更大的研究中得到证实。

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    《Prenatal Diagnosis》 |2014年第10期|共5页
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  • 正文语种 eng
  • 中图分类 妇科学;
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