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首页> 外文期刊>Biomechanics and modeling in mechanobiology >Remodelling of collagen fibre transition stretch and angular distribution in soft biological tissues and cell-seeded hydrogels
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Remodelling of collagen fibre transition stretch and angular distribution in soft biological tissues and cell-seeded hydrogels

机译：软组织和细胞接种水凝胶中胶原纤维过渡拉伸和角分布的重塑

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摘要

The extracellular matrix in many biological tissues is adapted to its mechanical environment. In this study, a phenomenological model for collagen remodelling is introduced that incorporates angular remodelling (fibre reorientation) and the adaptation of the so-called transition stretch. This is achieved by introducing a local stress-free configuration for the collagen network by a multiplicative decomposition of the deformation gradient and the appropriate definition of the anisotropic free Helmholtz energy potentials and structure tensors. The collagen network is either treated using discrete fibre directions or a continuous angular distribution. The first part of the study illustrates the influence of force- and displacement-controlled loading on either stress- or deformation-driven remodelling processes in tissues with various degrees of fibre reinforcement. The model is then applied to recent experimental studies of collagen remodelling, specifically periosteum adaptation (Foolen et al. in J Biomech 43(16):3168-3176, 2010), collagen gel (Thomopoulos et al. in J Biomech Eng 127(5):742- 750, 2005) and fibrin cruciform (Sander et al. inAnn Biomed Eng 1-16, 2010) compaction. The model is able to capture the basic effects of an adapting transition stretch over time in the periosteal simulations, as well as the compaction and the development of structural anisotropy in the collagen and fibrin gels. The model can potentially be applied to elucidate structure-function relationships, better interpret in vitro experiments involving collagen remodelling, and help investigate aspects of certain pathologies, such as connective tissue contracture.
机译：许多生物组织中的细胞外基质都适应其机械环境。在这项研究中，引入了胶原重塑的现象学模型，该模型结合了角度重塑（纤维重取向）和所谓过渡过渡的适应性。这是通过对变形梯度进行乘法分解以及各向异性自由亥姆霍兹能量势和结构张量的适当定义来引入胶原网络的局部无应力配置来实现的。可以使用离散的纤维方向或连续的角度分布来处理胶原蛋白网络。研究的第一部分说明了在不同程度的纤维增强情况下，力和位移控制的载荷对应力或变形驱动的重塑过程的影响。然后将该模型应用于胶原蛋白重塑的最新实验研究，特别是骨膜适应性研究（Foolen等人，J Biomech 43（16）：3168-3176，2010），胶原蛋白凝胶（Thomopoulos等人，J Biomech Eng 127（5） ）：742-750，2005）和纤维蛋白十字形（Sander等人，Ann Biomed Eng 1-16，2010）压实。该模型能够捕获骨膜模拟中随时间变化的适应性拉伸拉伸的基本效果，以及胶原蛋白和纤维蛋白凝胶的紧实性和结构各向异性的发展。该模型可潜在地用于阐明结构与功能的关系，更好地解释涉及胶原重构的体外实验，并有助于研究某些病理学方面，例如结缔组织挛缩。

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