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首页> 外文期刊>Preventive Medicine: An International Journal Devoted to Practice and Theory >Cognitive performance in relation to vitamin status in healthy elderly German women-the effect of 6-month multivitamin supplementation.
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Cognitive performance in relation to vitamin status in healthy elderly German women-the effect of 6-month multivitamin supplementation.

机译：健康的德国老年妇女与维生素状况相关的认知表现-补充6个月复合维生素的影响。

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BACKGROUND: Prior investigations have reported a link between poor status of antioxidants, folate, and cobalamin resulting in elevated total plasma homocysteine (tHcy) and methylmalonic acid (MMA) concentrations with an increased risk for reduced cognitive performance. The aim of the study was to evaluate the effect of a 6-month multivitamin supplementation on the cognitive performance of female seniors and to assess cognitive functioning in relation to vitamin status, tHcy, and MMA values at baseline. METHODS: The study was performed as a randomized placebo-controlled double-blind trial. 220 healthy, free-living women (aged 60-91 years) were included. Blood drawings and cognitive tests were performed at the Institute of Food Science of the University of Hanover, Germany. Vitamin and cognitive status have been evaluated prior to and 6 months after supplementation. Plasma ascorbic acid, serum concentrations of alpha-tocopherol, beta-carotene, and coenzyme Q10, serum and erythrocyte folate as well as serum cobalamin, serum MMA, and plasma tHcy concentrations were measured. Activity coefficient of erythrocyte alpha aspartic aminotransferase was used as functional index for vitamin B(6) status. The cognitive performance was assessed by the Symbol Search test, a subtest of the Wechsler Adult Intelligence Scale (WAIS-III) and the pattern-recognition test. Intelligence as assessed by the 'Kurztest fur Allgemeine Intelligenz' (KAI) was a further variable. RESULTS: No significant differences in pattern-recognition and intelligence score were observed between vitamin and placebo group prior to and after multivitamin supplementation. In the Symbol Search test, the vitamin group exhibited better test results than the placebo group at both measure points. One-way ANOVA showed a marginally significant linear trend between the baseline tHcy concentration and the pattern-recognition score (P = 0.051) in the total sample. Multiple backward regression revealed only a significant influence of the school graduation on baseline cognitive function test results. A general linear model showed that the changes in cognitive function scores could not be explained by the type of treatment or blood parameters. CONCLUSIONS: Our data indicate that 6 months supplementation of physiological dosages of antioxidants and B vitamins have no effect on cognitive performance in presumedly healthy and well-nourished female seniors. An intervention period of only 6 months may be too short for improving cognitive performance in well-educated elderly women without dementia.
机译：背景：先前的研究已经报道了抗氧化剂，叶酸和钴胺素的不良状态之间的联系，这导致血浆总同型半胱氨酸（tHcy）和甲基丙二酸（MMA）浓度升高，且认知能力下降的风险增加。这项研究的目的是评估6个月补充多种维生素对女性老年人认知能力的影响，并评估与基线时维生素状态，tHcy和MMA值相关的认知功能。方法：该研究是作为一项随机安慰剂对照双盲试验进行的。纳入220名健康，自由生活的妇女（60-91岁）。在德国汉诺威大学食品科学研究所进行了抽血和认知测试。在补充前和补充后六个月对维生素和认知状态进行了评估。测量血浆抗坏血酸，α-生育酚，β-胡萝卜素和辅酶Q10的血清浓度，血清和红细胞叶酸以及血清钴胺素，血清MMA和血浆tHcy浓度。红细胞α天冬氨酸氨基转移酶的活性系数用作维生素B（6）状态的功能指标。认知能力通过符号搜索测试，韦氏成人智力量表（WAIS-III）的子测试和模式识别测试进行评估。 “ Kurztest fur Allgemeine Intelligenz”（KAI）评估的智力是另一个变量。结果：在补充多种维生素之前和之后，维生素和安慰剂组之间在模式识别和智力得分方面没有观察到显着差异。在符号搜索测试中，在两个测量点上，维生素组的表现均优于安慰剂组。单向方差分析显示总样本中基线tHcy浓度与模式识别得分之间存在显着的线性趋势（P = 0.051）。多元向后回归显示，学校毕业对基线认知功能测试结果仅具有重大影响。一个通用的线性模型表明，认知功能评分的变化无法通过治疗类型或血液参数来解释。结论：我们的数据表明，在假定健康且营养丰富的女性老年人中，补充6个月生理剂量的抗氧化剂和B维生素对认知能力没有影响。对于没有受痴呆症影响的受过良好教育的老年妇女，只有6个月的干预时间可能不足以改善认知能力。

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