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首页> 外文期刊>Preventive Medicine: An International Journal Devoted to Practice and Theory >The conundrum of smoking cessation and weight gain
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The conundrum of smoking cessation and weight gain

机译：戒烟和体重增加的难题

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The signaling module that specifies nuclear factor-κΒ (NF-κB) activation is a three-component system: NF-κB, inhibitor of NF-κΒ (IκΒ), and IκΒ kinase complex (IKK). IKK receives upstream signals from the surface or inside the cell and converts itself into a catalytically active form, leading to the destruction of IκB in the inhibited IκB:NF-κB complex, leaving active NF-κB free to regulate target genes. Hidden within this simple module are family members that all can undergo various modifications resulting in expansion of functional spectrum. Three-dimensional structures representing all three components are now available. These structures have allowed us to interpret cellular observations in molecular terms and at the same time helped us to bring forward new concepts focused towards understanding the specificity in the NF-κB activation pathway.
机译：指定核因子-κB（NF-κB）激活的信号传导模块是一个三部分系统：NF-κB，NF-κB抑制剂（IκΒ）和IκΒ激酶复合物（IKK）。 IKK从细胞表面或细胞内部接收上游信号，并将其自身转化为催化活性形式，导致受抑制的IκB：NF-κB复合物中IκB破坏，而使活性NF-κB自由调节靶基因。这个简单的模块中隐藏着家族成员，它们都可以进行各种修改，从而扩展功能范围。现在可以使用代表所有三个组件的三维结构。这些结构使我们能够从分子角度解释细胞的观察结果，同时帮助我们提出了集中于理解NF-κB激活途径特异性的新概念。

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