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首页> 外文期刊>Psychiatric genetics >Cytochrome P450 2D6 polymorphism and character traits.
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Cytochrome P450 2D6 polymorphism and character traits.

机译：细胞色素P450 2D6多态性和性状特征。

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OBJECTIVEIt has been suggested that cytochrome P450 2D6 (CYP2D6) is involved in dopamine metabolism within the brain. The dopamine system is suggested to play a role in determining normal character. The purpose of this study was to examine whether character traits are dependent on cytochrome P450 2D6 activity.METHODSWe investigated the association between temperament and CYP2D6 gene polymorphism. The subjects were all Japanese and the polymorphism genotyped in the present study was CYP2D6*10. Character traits were assessed using the Temperament and Character Inventory.RESULTSThere was no overall or specific association between personality traits and the CYP2D6*10 allele and genotype frequencies.CONCLUSIONSThe present results do not support the hypothesis that CYP2D6 activity affects temperament and character.
机译：目的已提出细胞色素P450 2D6（CYP2D6）参与大脑内的多巴胺代谢。建议多巴胺系统在确定正常特征中起作用。本研究的目的是研究性格特征是否与细胞色素P450 2D6活性有关。方法我们研究了气质与CYP2D6基因多态性之间的关系。受试者均为日本人，本研究的基因型多态性为CYP2D6 * 10。结果：人格特质与CYP2D6 * 10等位基因和基因型频率之间没有整体或特定的联系。结论目前的结果不支持CYP2D6活性影响气质和性格的假说。

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