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首页> 外文期刊>Psychiatric genetics >Psychopathy trait scores in adolescents with childhood ADHD: the contribution of genotypes affecting MAOA, 5HTT and COMT activity.
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Psychopathy trait scores in adolescents with childhood ADHD: the contribution of genotypes affecting MAOA, 5HTT and COMT activity.

机译：青少年多动症青少年的精神病性状评分：影响MAOA，5HTT和COMT活动的基因型的贡献。

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OBJECTIVES: Psychopathy-related traits, especially those tapping the 'emotional dysfunction' aspect of psychopathy that is characterized by lack of emotional responsiveness, are thought to be of genetic origin, but molecular genetic studies are yet to be undertaken. Gene variants that affect COMT, MAOA and 5HTT activity have previously been linked to antisocial behaviour. The aims of this study were to test whether these gene variants are linked to psychopathy traits in attention-deficit hyperactivity disorder (ADHD). METHODS: Adolescents were followed up 5 years after an initial diagnosis of ADHD. Psychopathy trait scores were assessed [total scores and 'emotional dysfunction' (also referred to as 'affective') scores] and the MAOA 30-bp variable number of tandem repeats, SLC6A4 44-bp insertion/deletion and COMT Val158Met variants were genotyped. RESULTS: All three gene variants were associated with 'emotional dysfunction' scores. MAOA and 5HTT variants were associated with total psychopathy scores. The results were not explained by associated conduct disorder. CONCLUSION: The results suggest that specific gene variants influence psychopathy traits in ADHD.
机译：目的：与精神病有关的特征，特别是那些利用缺乏情绪反应性的精神病的“情绪机能障碍”方面的特征，被认为是遗传起源的，但是分子遗传学研究尚待进行。影响COMT，MAOA和5HTT活性的基因变体以前与反社会行为有关。这项研究的目的是测试这些基因变异是否与注意力缺陷多动障碍（ADHD）中的精神病特征有关。方法：在对ADHD进行初步诊断后的5年内对青少年进行随访。评估了精神病性状评分[总评分和'情绪障碍'（也称为'情感性'）评分]，并分析了MAOA 30 bp的串联重复序列可变数目，SLC6A4 44 bp插入/缺失和COMT Val158Met变异体的基因型。结果：所有三个基因变异均与“情绪障碍”评分相关。 MAOA和5HTT变异与总精神病评分有关。结果没有被相关的行为障碍所解释。结论：结果提示特定基因变异影响多动症的精神病性状。

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