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首页> 外文期刊>Progress in brain research >The response of adult oligodendrocyte progenitors to demyelination in EAE.
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The response of adult oligodendrocyte progenitors to demyelination in EAE.

机译：成年少突胶质细胞祖细胞对EAE中脱髓鞘的反应。

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摘要

Cells with the phenotypic characteristics of oligodendrocyte progenitors (NG2+/PDGF alpha R+/O4+) are found throughout the adult mammalian CNS in numbers similar to microglia. They are a reactive glial cell population and respond to demyelination by increasing in number, thereby repopulating the lesion site with cells capable of differentiating into remyelinating oligodendrocytes. Direct evidence that they differentiate into remyelinating cells is missing, although this is the most likely scenario. Cells with the same phenotype are found in normal human CNS tissue and also in chronic MS lesions. Further studies on this intriguing cell type are necessary in order to understand the molecular signals involved in their reaction to injury, particularly in multiple sclerosis.
机译：在整个成年哺乳动物中枢神经系统中发现具有少突胶质祖细胞（NG2 + / PDGFαR + / O4 +）表型特征的细胞，其数量与小胶质细胞相似。它们是反应性神经胶质细胞群体，并且通过增加数量来对脱髓鞘作出反应，从而用能够分化为重新形成髓鞘的少突胶质细胞的细胞重新填充病变部位。尽管这是最可能的情况，但缺少直接证据证明它们分化为髓鞘细胞。在正常人的CNS组织以及慢性MS病变中发现具有相同表型的细胞。为了了解这种分子对损伤（特别是多发性硬化症）反应所涉及的分子信号，有必要对这种有趣的细胞类型进行进一步的研究。

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