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首页> 外文期刊>Prostaglandins, Leukotrienes, and Essential Fatty Acids >Maternal dietary fat intake during gestation and lactation alters tissue fatty acid composition in the adult offspring of C57Bl/6 mice.
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Maternal dietary fat intake during gestation and lactation alters tissue fatty acid composition in the adult offspring of C57Bl/6 mice.

机译：妊娠和哺乳期间母体饮食脂肪的摄入会改变C57Bl / 6小鼠成年后代的组织脂肪酸组成。

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摘要

We investigated the effects of maternal dietary fat intake during gestation and lactation on the tissue fatty acid composition of the adult offspring. Female C57Bl/6 mice were fed high fat diets enriched with lard or safflower oil or chow during mating, gestation and lactation. The offspring obtained from each group of mothers were continued on diets rich in lard, safflower oil or chow post-weaning until 11 weeks of age. Livers and hearts were collected for fatty acid analysis. A maternal diet rich in safflower oil was associated with enrichment of hepatic tissue with n-3 polyunsaturated fatty acids in the offspring fed chow post-weaning compared to the offspring fed chow throughout. However, a continuous exposure to a safflower oil- as well as lard-rich diet during the pre- and post-weaning time periods was associated with reduced content of docosahexaenoic acid in both liver and heart tissues compared to the offspring fed chow throughout. In conclusion, this study demonstrated lasting effects of maternal dietary fat intake, as well as an interaction between pre- and post-weaning diets, on the tissue fatty composition in adult offspring.
机译：我们调查了孕期和哺乳期母体饮食脂肪摄入对成年后代组织脂肪酸组成的影响。在交配，妊娠和哺乳期间，给雌性C57Bl / 6小鼠喂食富含猪油或红花油或松花的高脂饮食。从每组母亲那里获得的后代继续食用富含猪油，红花油或断奶后的食物，直到11周龄。收集肝和心脏用于脂肪酸分析。与整个后代喂养的后代相比，富含红花油的孕妇饮食与断奶后后代的食物中的n-3多不饱和脂肪酸对肝脏组织的富集有关。然而，与整个后代喂食的后代相比，在断奶前和断奶后持续接触红花油和猪油丰富的饮食与肝脏和心脏组织中二十二碳六烯酸的含量降低有关。总之，这项研究证明了母体饮食脂肪摄入的持久影响以及断奶前后饮食之间的相互作用对成年后代组织脂肪组成的影响。

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