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首页> 外文期刊>The Journal of Nutritional Biochemistry >Intake of trans fatty acids during gestation and lactation leads to hypothalamic inflammation via TLR4/NF kappaBp65 signaling in adult offspring.
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Intake of trans fatty acids during gestation and lactation leads to hypothalamic inflammation via TLR4/NF kappaBp65 signaling in adult offspring.

机译：妊娠和哺乳期间摄入反式脂肪酸通过成年后代中的TLR4 / NF kappaBp65信号传导导致下丘脑炎症。

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摘要

We examined whether feeding pregnant and lactating rats with hydrogenated vegetable fats rich in trans fatty acids led to an increase in serum endotoxin levels and inflammation and to impaired satiety-sensing pathways in the hypothalamus of 90-day-old offspring. Pregnant and lactating Wistar rats were fed either a standard chow (Control) or one enriched with hydrogenated vegetable fat (Trans). Upon weaning, the male offspring were divided in two groups: Control-Control (CC), mothers and offspring fed the control diet; and Trans-Control (TC), mothers fed the trans diet, and offspring fed the control diet. The offspring's food intake and body weight were quantified weekly and the offspring were killed on the 90th day of life by decapitation. The blood and hypothalamus were collected from the offspring. Food intake and body weight were higher in the TC rats than in the CC rats. TC rats had increased serum endotoxin levels and increased hypothalamic cytokines, IL-6, TNF- alpha and IL1- beta, concentrations (P<.05). TLR4, NF kappaBp65 and MyD88 were higher (P<.05) in the TC rats than in the CC rats. AdipoR1 was lower in the TC rats than in the CC rats. Thus, the present study shows that the mothers' hydrogenated vegetable fat intake during pregnancy and lactation led to hypothalamic inflammation and impaired satiety-sensing, which promotes deleterious metabolic consequences such as obesity, even after the withdrawal of the causal factor. In other words, the effect remains after the consumption of the standard chow by offspring
机译：我们检查了用富含反式脂肪酸的氢化植物脂肪喂养妊娠和哺乳期大鼠是否会导致90天大后代下丘脑的血清内毒素水平和炎症增加，并削弱饱腹感通路。给怀孕的和哺乳期的Wistar大鼠喂标准的食物（对照）或富含氢化植物脂肪的动物（反式）。断奶后，将雄性后代分为两组：对照-对照（CC），母亲和后代喂养对照饮食;和反式对照（TC），母亲喂养反式饮食，后代喂养对照饮食。每周对后代的食物摄入量和体重进行定量，并在生命的第90天通过斩首将其杀死。从后代收集血液和下丘脑。 TC大鼠的食物摄入量和体重高于CC大鼠。 TC大鼠的血清内毒素水平升高，下丘脑细胞因子IL-6，TNF-α和IL1-β浓度升高（P <0.05）。 TC大鼠中的TLR4，NF kappaBp65和MyD88高于CC大鼠（P <.05）。 TC大鼠的AdipoR1低于CC大鼠。因此，本研究表明，母亲在怀孕和哺乳期间摄入的氢化植物脂肪导致下丘脑炎症和饱腹感受损，即使在消除因果关系后，也会促进有害的代谢后果，例如肥胖。换句话说，后代食用标准食物后，效果仍然存在

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