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首页> 外文期刊>Quality of life research: An international journal of quality of life aspects of treatment, care and rehabilitation >Self-reported health-related quality of life of children and adolescent survivors of extracranial childhood malignancies: a Finnish nationwide survey.
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Self-reported health-related quality of life of children and adolescent survivors of extracranial childhood malignancies: a Finnish nationwide survey.

机译：自我报告的颅外儿童恶性肿瘤儿童和青少年幸存者的健康相关生活质量：芬兰全国范围的调查。

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PURPOSE: The purpose of this Finnish total cohort survey was to assess and compare the self-reported health-related quality of life (HRQL) in childhood cancer survivors to that of matched controls, to analyse demographic and disease-related factors explaining survivors' HRQL, and to compare the results of two different HRQL instruments, 16D/17D and PedsQL. METHODS: Questionnaires were mailed to 384 childhood cancer survivors and their randomly selected gender-, age- and living place-matched controls. Eligible survivors (aged 11-18 years) had been treated for extracranial malignancies /=4 years after the diagnosis, and were currently free of cancer. RESULTS: Of them, 203 (52.9%) survivors and 266 (30.4%) controls replied. Survivors reported higher HRQL than their controls. Diagnostic group, additional non-cancer diagnosis, need of remedial education, and self-rated unhappiness correlated significantly with HRQL. The survivors of Wilms tumor, or neuroblastoma, had lower HRQL scores than the reference group (leukemia). The studied variables explained only 28% of the variation in HRQL scores among survivors. Instrument correlations were moderate (R = 0.40-0.65). CONCLUSIONS: Our findings suggest that the diagnosis of Wilms tumor or neuroblastoma may carry substantial risks for lower HRQL. The available background variables, however, explained less than one-third of the variation in the HRQL scores. Thus, other factors than demographic or cancer-related seem to play a significant role as determinants of HRQL.
机译：目的：本次芬兰总体队列调查的目的是评估和比较儿童癌症幸存者与相应对照者的自我报告的健康相关生活质量（HRQL），以分析人口统计学和疾病相关因素来解释幸存者的HRQL ，并比较两种不同的HRQL仪器16D / 17D和PedsQL的结果。方法：将问卷调查表邮寄给384名儿童癌症幸存者及其随机选择的性别，年龄和居住地点匹配的对照组。符合条件的幸存者（11至18岁）已接受颅外恶性肿瘤治疗，≤16岁，在诊断后存活> / = 4年，目前没有癌症。结果：其中有203名（52.9％）幸存者和266名（30.4％）的对照组回答。幸存者报告的HRQL高于对照组。诊断组，其他非癌症诊断，需要进行补救教育以及自我评估的不快乐与HRQL显着相关。 Wilms肿瘤或神经母细胞瘤的幸存者的HRQL得分低于参考组（白血病）。研究变量仅解释了幸存者中HRQL分数变化的28％。仪器相关性中等（R = 0.40-0.65）。结论：我们的发现表明，Wilms肿瘤或成神经细胞瘤的诊断可能会带来降低HRQL的重大风险。但是，可用的背景变量无法解释HRQL分数变化的三分之一。因此，人口统计学或癌症相关因素以外的其他因素似乎在HRQL的决定因素中起着重要作用。

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