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首页> 外文期刊>Pulmonary pharmacology & therapeutics >Toxicity of prolonged high dose inhaled PGE(1) in ventilated neonatal pigs.
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Toxicity of prolonged high dose inhaled PGE(1) in ventilated neonatal pigs.

机译：长期通风吸入的新生猪的PGE（1）的毒性。

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OBJECTIVE: To study the toxicity of inhaled PGE(1) (IPGE(1)) in healthy ventilated piglets. METHODS: Mechanically ventilated anesthetized piglets received either high dose IPGE(1) (IPGE(1) group) or nebulized saline (control group) continuously for 24h. Cardio-respiratory parameters, complete blood counts and serum electrolytes were monitored. Lung histology was evaluated by a masked pathologist for the severity (minimal, moderate, and severe) and extent (focal, multifocal, and diffuse) of histologic injury. RESULTS: Ten neonatal pigs were instrumented. Four received nebulized saline and six received high dose IPGE(1). There was no evidence of adverse cardio-respiratory effects, bronchial irritation or hypernatremia related to IPGE(1). Diffuse/multifocal alveolar edema and focal polymorphonuclear infiltration was observed in both the control and IPGE(1) groups suggesting that alveolar alterations may be secondary to effects of mechanical ventilation. The most distinct histomorphological abnormalities observed in the IPGE(1) animals were focal ulceration, flattening of the bronchial epithelium and loss of cilia of moderate to severe degree in the trachea and bronchi. CONCLUSION: In healthy piglets, inhalation of high dose IPGE(1) was not associated with adverse cardiorespiratory effects, bronchial irritation, or hypernatremia and produced minimal signs of pulmonary toxicity even after 24h. Prolonged inhalation of high dose PGE(1) therefore appears safe in newborn piglets.
机译：目的：研究吸入PGE（1）（IPGE（1））对健康通风仔猪的毒性。方法：机械通气麻醉的仔猪连续24h接受高剂量IPGE（1）（IPGE（1）组）或雾化盐水（对照组）。监测心脏呼吸参数，全血细胞计数和血清电解质。一位戴着面具的病理学家对肺组织学进行了组织学损伤的严重程度（最小，中度和严重）和程度（局部，多灶和弥散）评估。结果：检测了十只新生猪。四名接受雾化盐水，六名接受高剂量IPGE（1）。没有证据表明与IPGE（1）相关的不良心脏呼吸作用，支气管刺激或高钠血症。在对照组和IPGE（1）组均观察到弥漫性/多灶性肺泡水肿和局灶性多形核浸润，提示肺泡改变可能是机械通气作用的继发因素。在IPGE（1）动物中观察到的最明显的组织形态异常是局灶性溃疡，支气管上皮变平以及气管和支气管中度至重度纤毛的流失。结论：在健康的仔猪中，吸入大剂量IPGE（1）与不良的心肺呼吸作用，支气管刺激或高钠血症无关，即使在24小时后仍能产生最小的肺毒性迹象。因此，在新生仔猪中长期吸入大剂量PGE（1）似乎是安全的。

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