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首页> 外文期刊>Psychiatry Research. Neuroimaging >The relation of worry to prefrontal cortex volume in older adults with and without generalized anxiety disorder
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The relation of worry to prefrontal cortex volume in older adults with and without generalized anxiety disorder

机译：有和没有广泛性焦虑症的老年人忧虑与前额叶皮层体积的关系

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Despite the widespread prevalence of generalized anxiety disorder (GAD) in later life, almost nothing is known about the neural aspects of worry in adults over the age of 60. Given the ongoing rapid increase in the older adult population, the relatively poor response rates to current interventions for late life GAD, and the effects of age-related changes to the brain, additional research on worry neurobiology is needed. The study group comprised 15 older GAD patients and 15 matched controls who were compared on clinical measures and brain volumes. It was expected that prefrontal cortex (PFC) volumes [medial orbital cortex (mOFC), dorsolateral cortex (DLPFC)] would show positive relations to worry scores, and weaker relations to more general measures of anxiety and depression. Negative relations were expected between amygdala volumes and worry scores. As expected, mOFC volumes were positively related to worry scores; however, DLPFC and amygdala volumes were not. The mOFC is involved in emotional decision-making under uncertain conditions and has the ability to suppress the amygdala, both of which are hypothesized functions of worry. Results are partly consistent with GAD theory and suggest that worry may involve neural areas that are also involved in the successful control of anxiety.
机译：尽管在以后的生活中普遍存在广泛性焦虑症（GAD），但对于60岁以上成年人的神经担心方面几乎一无所知。鉴于老年人口的持续增长，对儿童的反应率相对较差当前针对晚期GAD的干预措施以及与年龄相关的大脑变化的影响，还需要对神经生物学担心进行更多研究。该研究组包括15位老年GAD患者和15位相匹配的对照组，对他们的临床指标和脑容量进行了比较。预计前额叶皮层（PFC）的量[内侧眶皮层（mOFC），背外侧皮层（DLPFC）]与焦虑评分之间呈正相关，而与焦虑和抑郁的更一般衡量指标之间则较弱。杏仁核数量和忧虑评分之间预期为负相关。不出所料，mOFC量与忧虑评分呈正相关;但是，DLPFC和杏仁核的体积却没有。 mOFC参与不确定条件下的情绪决策，并具有抑制杏仁核的能力，这两种功能都是假设的担心功能。结果部分与GAD理论一致，表明担心可能涉及神经区域，而神经区域也与焦虑的成功控制有关。

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