• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Psychiatry Research. Neuroimaging >Evidence of successful modulation of brain activation and subjective experience during reappraisal of negative emotion in unmedicated depression
【24h】

Evidence of successful modulation of brain activation and subjective experience during reappraisal of negative emotion in unmedicated depression

机译：重新评估未经药物治疗的抑郁症患者的负面情绪时，大脑激活和主观经验得到成功调节的证据

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Functional magnetic resonance imaging (fMRI) was used to examine cognitive regulation of negative emotion in 12 unmedicated patients with major depressive disorder (MDD) and 24 controls. The participants used reappraisal to increase (real condition) and reduce (photo condition) the personal relevance of negative and neutral pictures during fMRI as valence ratings were collected; passive viewing (look condition) served as a baseline. Reappraisal was not strongly affected by MDD. Ratings indicated that both groups successfully reappraised negative emotional experience. Both groups also showed better memory for negative vs. neutral pictures 2 weeks later. Across groups, increased brain activation was observed on negative/ real vs. negative/ look and negative/ photo trials in left dorsolateral prefrontal cortex (DLPFC), rostral anterior cingulate, left parietal cortex, caudate, and right amygdala. Depressive severity was inversely correlated with activation modulation in the left DLPFC, right amygdala, and right cerebellum during negative reappraisal. The lack of group differences suggests that depressed adults can modulate the brain activation and subjective experience elicited by negative pictures when given clear instructions. However, the negative relationship between depression severity and effects of reappraisal on brain activation indicates that group differences may be detectable in larger samples of more severely depressed participants.
机译：功能磁共振成像（fMRI）用于检查12例重度抑郁症（MDD）的非药物治疗患者和24例对照的负性情绪的认知调节。参加者使用重新评估来增加（真实状态）和减少（照片状态）fMRI期间负性和中性图片的个人相关性，因为这是对价数的评估。被动观看（观看条件）作为基准。重新评估不受MDD的强烈影响。评级表明，两组都成功地重新评估了负面情绪体验。两组在2周后对中性图片的消极记忆也更好。在各组中，在左侧背外侧前额叶皮层（DLPFC），前额扣带回，左侧顶叶皮质，尾状和右侧杏仁核的阴性/真实对比阴性/外观和阴性/照片试验中观察到了大脑激活的增加。在阴性重新评估期间，抑郁的严重程度与左DLPFC，右杏仁核和右小脑的激活调节呈负相关。缺乏群体差异表明，如果给出明确的说明，沮丧的成年人可以调节负面图片引起的大脑激活和主观体验。但是，抑郁症严重程度与重新评估对大脑激活的影响之间的负相关关系表明，在抑郁症较重的参与者的较大样本中，可以检测到群体差异。

著录项

相似文献

  • 外文文献
  • 中文文献
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号