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首页> 外文期刊>Psychiatry Research. Neuroimaging >Impaired integrity of the brain parenchyma in non-geriatric patients with major depressive disorder revealed by diffusion tensor imaging
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Impaired integrity of the brain parenchyma in non-geriatric patients with major depressive disorder revealed by diffusion tensor imaging

机译：弥散张量成像显示非老年重症抑郁症患者的脑实质完整性受损

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摘要

Diffusion tensor imaging (DTI) is considered to be able to non-invasively quantify white matter integrity. This study aimed to use DTI to evaluate white matter integrity in non-geriatric patients with major depressive disorder (MDD) who were free of antidepressant medication. DTI was performed on 19 non-geriatric patients with MDD, free of antidepressant medication, and 19 age-matched healthy subjects. Voxel-based and histogram analyses were used to compare fractional anisotropy (FA) and mean diffusivity (MD) values between the two groups, using two-sample t tests. The abnormal DTI indices, if any, were tested for correlation with disease duration and severity, using Pearson product-moment correlation analysis. Voxel-based analysis showed clusters with FA decrease at the bilateral frontal white matter, anterior limbs of internal capsule, cerebellum, left putamen and right thalamus of the patients. Histogram analysis revealed lower peak position of FA histograms in the patients. FA values of the abnormal clusters and peak positions of FA histograms of the patients exhibited moderate correlation with disease duration and severity. These results suggest the implication of frontal-subcortical circuits and cerebellum in MDD, and the potential utility of FA in evaluation of brain parenchymal integrity.
机译：扩散张量成像（DTI）被认为能够无创地量化白质完整性。这项研究旨在使用DTI评估没有抗抑郁药的非老年重症抑郁症（MDD）患者的白质完整性。在19名非抗抑郁药物的非老年患者中进行了DTI治疗，无抗抑郁药和19名年龄匹配的健康受试者。使用两次样本t检验，使用基于体素的数据和直方图分析比较两组之间的分数各向异性（FA）和平均扩散率（MD）值。使用Pearson乘积矩相关分析，测试了异常DTI指数（如果有）与疾病持续时间和严重程度的相关性。基于体素的分析显示，患者双侧额叶白质，内囊前肢，小脑，左壳核和右丘脑的FA减少。直方图分析显示患者中FA直方图的峰值位置较低。患者的异常簇的FA值和FA直方图的峰值位置与疾病的持续时间和严重程度呈中等程度的相关性。这些结果表明额叶皮层下回路和小脑在MDD中的含义，以及FA在评估脑实质完整性中的潜在效用。

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