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首页> 外文期刊>Psychiatry Research. Neuroimaging >Further understanding of the comorbidity between attention-deficit/hyperactivity disorder and bipolar disorder in adults: An MRI study of cortical thickness
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Further understanding of the comorbidity between attention-deficit/hyperactivity disorder and bipolar disorder in adults: An MRI study of cortical thickness

机译：对成年人注意缺陷/多动障碍和双相情感障碍之间的合并症的进一步理解：皮质厚度的MRI研究

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Although Attention-Deficit/Hyperactivity Disorder (ADHD) and Bipolar Disorder (BPD) frequently co-occur and represent a particularly morbid clinical form of both disorders, neuroimaging research addressing this comorbidity is scarce. Our aim was to evaluate cortical thickness in ADHD and BPD, testing the hypothesis that comorbid subjects (ADHD. +. BPD) would have neuroanatomical correlates of both disorders. Magnetic Resonance Imaging (MRI) findings were compared between 31 adults with ADHD. +. BPD, 18 with BPD, 26 with ADHD, and 23 healthy controls. Cortical thickness analysis of regions of interest was estimated as a function of ADHD and BPD status, using linear regression models. BPD was associated with significantly thicker cortices in 13 regions, independently of ADHD status and ADHD was associated with significantly thinner neocortical gray matter in 28 regions, independent of BPD. In the comorbid state of ADHD plus BPD, the profile of cortical abnormalities consisted of structures that are altered in both disorders individually. Results support the hypothesis that ADHD and BPD independently contribute to cortical thickness alterations of selective and distinct brain structures, and that the comorbid state represents a combinatory effect of the two. Attention to comorbidity is necessary to help clarify the heterogeneous neuroanatomy of both BPD and ADHD.
机译：尽管注意力缺陷/多动障碍（ADHD）和双相情感障碍（BPD）经常并发并且代表两种疾病的特别病态的临床形式，但针对这种合并症的神经影像学研究很少。我们的目的是评估ADHD和BPD中的皮质厚度，检验假说合并症患者（ADHD。+。BPD）可能与这两种疾病的神经解剖学相关。比较了31位患有ADHD的成年人的磁共振成像（MRI）结果。 +。 BPD，18名BPD，26名ADHD和23名健康对照。使用线性回归模型，将感兴趣区域的皮质厚度分析估计为ADHD和BPD状态的函数。 BPD与13个区域的皮质明显增厚相关，而与ADHD状态无关，ADHD与28个区域的皮质皮质明显变薄相关，而与BPD无关。在多动症加BPD的合并症中，皮质异常的特征由两种疾病各自改变的结构组成。结果支持以下假设：ADHD和BPD独立地影响选择性和不同大脑结构的皮质厚度改变，而共病状态代表两者的组合作用。注意合并症是必要的，以帮助阐明BPD和ADHD的异质神经解剖学。

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