Chiral bisphosphazides as dual basic enantioselective catalysts

Naka H; Kanase N; Ueno M; Kondo Y

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Chiral bisphosphazides as dual basic enantioselective catalysts

机译：手性双磷叠氮化物作为双碱性对映选择性催化剂

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Chiral bisphosphazides complexed with lithium salts efficiently catalyze the direct enantioselective 1,4-addition of dialkyl malonates to acyclic enones. Spectroscopic studies on the stoichiometry of the bisphosphazide and lithium salt have indicated the formation of a 1:1 species as the active enantioselective catalyst. It is suggested that the catalyst generates a complex of the protonated phosphazide and the chiral nucleophile as the key intermediate. The phosphazide moiety appears to be a promising dual basic functionality for stereo- and chemoselective catalytic transformations.

机译：与锂盐络合的手性二磷叠氮化物可有效催化丙二酸二烷基酯向无环烯酮的直接对映选择性1,4-加成反应。关于双磷叠氮化物和锂盐的化学计量的光谱研究表明，形成了1：1的物种作为活性对映选择性催化剂。建议该催化剂产生质子化的磷叠氮化物和手性亲核试剂作为关键中间体的复合物。磷腈部分似乎是有前途的立体和化学选择性催化转化的双重基本功能。

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《Chemistry: A European journal》 |2008年第17期|共8页
作者
Naka H; Kanase N; Ueno M; Kondo Y;
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正文语种 eng
中图分类化学;
关键词
asymmetric catalysis; basicity; lithium; Michael addition; phosphazene base; C BOND FORMATION; PHOSPHAZENE BASE; STAUDINGER REACTION; ASYMMETRIC CATALYSIS; CONJUGATE ADDITION; T-BU-P4 BASE; SIDE-GROUPS; DERIVATIVES; EFFICIENT; FUNCTIONALIZATION;

机译：不对称催化;碱度;锂;迈克尔加成;磷腈碱;C键形成;磷腈碱;施陶丁格反应;不对称催化;共轭加成;T-BU-P4碱;侧基团;衍生物;高效;功能化;

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1. Chiral bisphosphazides as dual basic enantioselective catalysts [J] . Naka H, Kanase N, Ueno M, Chemistry: A European journal . 2008,第17期

机译：手性双磷叠氮化物作为双碱性对映选择性催化剂
2. Enantioselective silyl protection of alcohols promoted by a combination of chiral and achiral Lewis basic catalysts [J] . Nathan Manville, Hekla Alite, Fredrik Haeffner Nature Chemistry . 2013,第9期

机译：手性和非手性Lewis碱性催化剂的组合促进醇的对映选择性甲硅烷基保护
3. Importance of chiral phase-transfer catalysts with dual functions in obtaining high enantioselectivity in the Michael reaction of malonates and chalcone derivatives [J] . Ooi T, Ohara D, Fukumoto K, Organic letters . 2005,第15期

机译：具有双功能的手性相转移催化剂在丙二酸酯和查尔酮衍生物的迈克尔反应中获得高对映选择性的重要性
4. Tris(pentafluorophenyl)borane-Assisted Chiral Phosphoric Acid Catalysts for Enantioselective Carbonyl–Ene Cyclization [C] . Takuya Mochizuki, Hideyuki Ishihara, Manabu Hatano 日本化学会春季年会講演予稿集 . 2018

机译：TRIS（五氟苯基）硼烷辅助手性磷酸催化剂用于对映选择性羰基烯化环化
5. Structure optimization studies on imidazoline based enantioselective acyl transfer catalysts. Development of chiral 2-(o-iodoxyphenyl)-oxazolines as enantioselective oxidants [D] . Boppisetti, Jagadish Kumar 2009

机译：基于咪唑啉的对映选择性酰基转移催化剂的结构优化研究。手性2-（邻碘氧基苯基）-恶唑啉作为对映选择性氧化剂的开发
6. Enantioselective Silyl Protection of Alcohols Promoted by a Combination of Chiral and Achiral Lewis Basic Catalysts [O] . Nathan Manville, Hekla Alite, Fredrik Haeffner, -1

机译：手性和非手性路易斯碱性催化剂的组合促进醇的对映选择性硅烷保护
7. Design of New Chiral Phase-Transfer Catalysts with Dual Functions for Highly Enantioselective Epoxidation of a, b-Unsaturated Ketones [O] . -1

机译：具有双函数的新型手性相转移催化剂的设计，用于A，B-不饱和酮高对映选择性环氧化

Chiral bisphosphazides as dual basic enantioselective catalysts

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