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首页> 外文期刊>Psychiatry Research. Neuroimaging >Correlation between amygdala volume and age in bipolar disorder - A systematic review and meta-analysis of structural MRI studies
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Correlation between amygdala volume and age in bipolar disorder - A systematic review and meta-analysis of structural MRI studies

机译：躁郁症患者杏仁核体积与年龄之间的相关性-结构性MRI研究的系统评价和荟萃分析

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The amygdala has gained special interest regarding the neuropathology of bipolar disorder (BD). Structural magnetic resonance imaging (MRI) studies with patients suffering from BD have yielded quite inconsistent results with respect to amygdala volume. We performed a meta-analysis of structural MRI studies that investigated right and left amygdala volume in pediatric and adult patients with BD. The aim was to assess the heterogeneous findings and to investigate whether a correlation between amygdala volume and the patient's age exists. Studies were searched for in "Pub Med" (last search June 2007), and data for right and left amygdala volume in cm3 were extracted and combined in a meta-analysis. Thirteen studies with 389 scans of patients and 488 scans of healthy control subjects (HC) were included. The impact of age on the difference in amygdala volume between patients and HC was assessed by meta-regression. The amygdala volume was bilaterally reduced in the overall sample of patients with BD and the pediatric subsample. The results of the adult studies were less homogeneous, and on average, no significant difference between adult patients and HC was found. A meta-regression analysis revealed a positive correlation between mean age and amygdala volume in patients with BD. We speculate that amygdala volume is reduced at the onset of the disease and increases with age.
机译：杏仁核对双相情感障碍（BD）的神经病理学引起了特别的兴趣。对患有BD的患者的结构磁共振成像（MRI）研究在杏仁核体积方面得出的结果非常不一致。我们进行了结构MRI研究的荟萃分析，该研究调查了小儿和成年BD患者的左右杏仁核体积。目的是评估异质性发现并调查杏仁核体积与患者年龄之间是否存在相关性。在“ Pub Med”（最后一次搜索，2007年6月）中搜索研究，提取以cm3为单位的左右杏仁核体积数据，并进行荟萃分析。包括13项研究，其中包括389例患者的扫描和488例健康对照对象（HC）的扫描。通过荟萃回归评估年龄对患者与HC之间杏仁核体积差异的影响。在BD患者的总体样本和儿科亚样本中，杏仁核体积双侧减少。成人研究的结果不太统一，平均而言，成人患者和HC之间没有发现显着差异。荟萃回归分析显示，BD患者的平均年龄与杏仁核体积呈正相关。我们推测杏仁核的体积在疾病发作时会减少，并随着年龄的增长而增加。

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