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首页> 外文期刊>Psychiatry Research. Neuroimaging >Gender, personality, and serotonin-2A receptor binding in healthy subjects
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Gender, personality, and serotonin-2A receptor binding in healthy subjects

机译：健康受试者的性别，性格和血清素2A受体结合

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摘要

The vulnerability to mood disorders, impulsive-aggression, eating disorders, and suicidal behavior varies greatly with gender, and may reflect gender differences in central serotonergic function. We investigated the relationships of gender, mood, impulsivity, aggression and temperament to 5HT_(2A) receptor binding in 21 healthy subjects using [~(18)F]altanserin and PET neuroimaging. Binding potentials in pre-defined regions-of-interest (ROI) were calculated using the Logan graphical method, corrected for partial volume effects, and compared by gender with age co-varied. SPM analysis was used for voxel level comparisons. Altanserin binding (BP_P) was greater in male than female subjects in the following nine ROIs: hippocampus (HIP) and Lt. HIP, lateral orbital frontal cortex (LOF) and Lt.LOF, left medial frontal cortex (Lt.MFC), left medial temporal cortex (Lt. MTC), left occipital cortex (Lt OCC), thalamus (THL) and Lt THL Differences in Lt. HIP and Lt MTL remained significant after Bonferroni correction. Gender differences were noted in the co-variation of psychological traits with BP_P values in Lt. LOF and Lt MFC, and Suspiciousness positively correlated in LOF, Lt LOF and Lt. MFC. Among female subjects alone, Negativism was positively correlated with BPP values in HIP, and Verbal Hostility in Lt HIP. Altanserin binding in Lt. MTC was positively correlated with Persistence, with no significant gender effect. Gender differences in 5HT_(2A) receptor function in specific ROIs may mediate expression of psychological characteristics such as aggression, suspiciousness and negativism. Future studies of 5HT_(2A) receptor function and its relationship to behavior should control for gender.
机译：易患情绪障碍，冲动攻击，进食障碍和自杀行为的脆弱性随性别而变化很大，并且可能反映出中央血清素能功能中的性别差异。我们使用[〜（18）F] altanserin和PET神经成像技术研究了21名健康受试者中性别，情绪，冲动，攻击性和气质与5HT_（2A）受体结合的关系。使用Logan图形方法计算预定义的感兴趣区域（ROI）中的结合电位，对部分体积效应进行校正，并按性别与年龄进行比较。 SPM分析用于体素水平比较。在以下9个ROI中，男性受试者的阿坦色林结合（BP_P）高于女性：海马（HIP）和Lt. HIP，眶外侧额叶皮层（LOF）和Lt.LOF，左内侧额叶皮层（Lt.MFC），左Bonferroni矫正后，Ht和Lt MTL的差异仍然很明显。内侧颞叶皮层（Lt. MTC），左枕皮层（Lt OCC），丘脑（THL）和Lt THL的差异。在Lt. LOF和Lt MFC的心理特征与BP_P值的共变中注意到性别差异，而LOF，Lt LOF和Lt. MFC的可疑性正相关。仅在女性受试者中，消极情绪与HIP中的BPP值和Lt HIP中的言语敌意呈正相关。 Mt中山中阿坦色林的结合与持久性呈正相关，没有明显的性别效应。特定ROI中5HT_（2A）受体功能的性别差异可能会介导攻击性，可疑性和否定性等心理特征的表达。 5HT_（2A）受体功能及其与行为的关系的未来研究应控制性别。

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