• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Psychiatry Research. Neuroimaging >Serotonin transporter genotype modulates the association between depressive symptoms and amygdala activity among psychiatrically healthy adults.
【24h】

Serotonin transporter genotype modulates the association between depressive symptoms and amygdala activity among psychiatrically healthy adults.

机译：血清素转运蛋白基因型调节精神病健康成年人的抑郁症状与杏仁核活动之间的关联。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Recent attempts to understand the biological bases of depression vulnerability have revealed that both the short allele of the serotonin transporter-linked polymorphic region (5-HTTLPR) and activity in the amygdala are associated with depression. Other studies have reported amygdala hyperactivity associated with the 5-HTTLPR short allele, linking the genetic and neuroimaging lines of research and suggesting a mechanism whereby the short allele confers depression risk. However, fewer investigations have examined the associations among depression, 5-HTTLPR variability, and amygdala activation in a single study. The current study thus investigated whether 5-HTTLPR genotype modulates the association between depressive symptoms and amygdala activity among psychiatrically healthy adults. Regional cerebral blood flow was measured with perfusion fMRI during a task-free scan. We hypothesized differential associations between depressive symptoms and amygdala activity among individuals homozygous for the short allele and individuals homozygous for the long allele. Both whole brain analyses and region-of-interest analyses confirmed this prediction, revealing a significant negative association among the long allele group and a trend of positive association among the short allele group. These results complement existing reports of short allele related amygdala hyperactivity and suggest an additional neurobiological mechanism whereby the 5-HTTLPR is associated with psychiatric outcomes.
机译：最近了解抑郁症脆弱性生物学基础的尝试表明，5-羟色胺转运蛋白连锁多态性区域（5-HTTLPR）的短等位基因和杏仁核的活动均与抑郁症相关。其他研究已经报道了与5-HTTLPR短等位基因相关的杏仁核过度活跃，将遗传和神经影像学研究联系在一起，并提出了短等位基因赋予抑郁风险的机制。但是，在一项研究中，很少有研究检查抑郁症，5-HTTLPR变异性和杏仁核激活之间的关联。因此，当前的研究调查了5-HTTLPR基因型是否调节精神病健康成年人的抑郁症状与杏仁核活动之间的关联。在无任务扫描期间，通过灌注fMRI测量了局部脑血流量。我们假设在短等位基因纯合的个体和长等位基因纯合的个体之间，抑郁症状与杏仁核活性之间存在差异关联。全脑分析和感兴趣区域分析都证实了这一预测，揭示了长等位基因组之间的显着负相关和短等位基因组之间的正相关趋势。这些结果补充了有关短等位基因相关的杏仁核过度活跃的现有报道，并提出了一种额外的神经生物学机制，其中5-HTTLPR与精神病学预后相关。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号