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首页> 外文期刊>Psychiatry Research. Neuroimaging >Cerebellum volume in high-risk offspring from multiplex alcohol dependence families: Association with allelic variation in GABRA2 and BDNF
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Cerebellum volume in high-risk offspring from multiplex alcohol dependence families: Association with allelic variation in GABRA2 and BDNF

机译：来自多重酒精依赖家族的高危后代的小脑体积：与GABRA2和BDNF等位基因变异的关联

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Offspring from families with multiple cases of alcohol dependence have a greater likelihood of developing alcohol dependence (AD) and related substance use disorders. Greater susceptibility for developing these disorders may be related to structural differences in brain circuits that influence the salience of rewards or modify the efficiency of information processing and AD susceptibility. We examined the cerebellum of 71 adolescent/young adult high-risk (HR) offspring from families with multiple cases of alcohol dependence (multiplex families), and 60 low-risk (LR) controls with no family history of alcohol or drug dependence who were matched for age, gender, socioeconomic status and IQ, with attention given to possible effects of personal use of substances and maternal use during pregnancy. Magnetic resonance images were acquired on a General Electric 1.5-Tesla scanner and manually traced (BRAINS2) blind to clinical information. GABRA2 and BDNF variation were tested for their association with cerebellar volumes. High-risk offspring from multiplex AD families showed greater total volume of the cerebellum and total gray matter (GM), in comparison with LR controls. An interaction between allelic variation in GABRA2 and BDNF genes was associated with GM volumes, suggesting that inherited variation in these genes may promote early developmental differences in neuronal proliferation of the cerebellum.
机译：来自患有多种酒精依赖病例的家庭的后代更有可能发展酒精依赖（AD）和相关的物质使用障碍。发生这些疾病的更大敏感性可能与大脑回路的结构差异有关，这种结构差异影响奖励的显着性或改变信息处理和AD敏感性的效率。我们检查了71名来自多名酒精依赖病例家庭的青少年/年轻人高危（HR）后代的小脑（多重家庭），以及60位无酒精或药物依赖家族史的低风险（LR）对照。匹配年龄，性别，社会经济地位和智商，并注意个人使用药物和孕妇在怀孕期间可能产生的影响。在General Electric 1.5-Tesla扫描仪上获取磁共振图像，并手动跟踪（BRAINS2）对临床信息无知。测试了GABRA2和BDNF变异与小脑体积的关系。与LR对照相比，来自多重AD家族的高危后代显示小脑和总灰质（GM）的总体积更大。 GABRA2和BDNF基因的等位基因变异之间的相互作用与GM量相关，这表明这些基因中的遗传变异可能促进小脑神经元增殖的早期发育差异。

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