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首页> 外文期刊>Psychiatry Research. Neuroimaging >A DTI study on the corpus callosum of treatment-naive boys with 'pure' Tourette syndrome
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A DTI study on the corpus callosum of treatment-naive boys with 'pure' Tourette syndrome

机译：DTI研究未治疗过的“纯”图雷特综合症男孩的call体

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摘要

Disturbances in the corpus callosum (CC) indicating altered interhemispheric connectivity have been associated with Tourette syndrome (TS). The objective of the present study was to refine knowledge about interhemispheric connectivity in TS by analyzing four different diffusion tensor imaging (DTI) parameters in a very homogeneous group of treatment-nave boys with pure TS in comparison to male healthy controls (HC). Fractional anisotropy (FA), radial diffusivity (RD), axial diffusivity (AD) and mean diffusivity (MD) of five CC-segments were assessed from DTI of 26 treatment-nave boys with pure TS and 24 HC. We observed no group differences in both FA and RD. However, we found a significant effect for AD and a trend for MD, being both reduced in boys with TS in comparison to HC. Moreover, a negative correlation between AD and the Yale Global Tic Severity Scale total score was observed. Reduced AD of the CC in treatment-naive boys with pure TS in comparison to HC may indicate that significant alterations in white matter microstructure of the CC contribute to tic symptomatology per se and seem not to be related to confounders such as consequences of long-term medication, tic performance or tic suppression. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
机译：indicating体（CC）的紊乱表明半球之间的连通性发生了改变，这与图雷特综合症（TS）有关。本研究的目的是通过分析与纯净TS相比男性同等健康对照（HC）的同质治疗纯男孩中的四个不同扩散张量成像（DTI）参数，来完善关于TS中半球连接的知识。从26名纯TS和24 HC治疗裸男的DTI中评估了五个CC段的分数各向异性（FA），径向扩散率（RD），轴向扩散率（AD）和平均扩散率（MD）。我们没有观察到FA和RD的组差异。但是，我们发现与HC相比，患有TS的男孩均对AD有显着影响，而MD则有趋势。此外，观察到AD与耶鲁全球Tic严重度量表总分之间呈负相关。与HC相比，纯净TS的未治疗男孩中CC的AD降低可能表明CC的白质微观结构的显着改变本身会导致抽动症状，似乎与混杂因素（如长期后果）无关用药，抽动表现或抽动抑制。 （C）2015 Elsevier Ireland Ltd.保留所有权利。

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