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首页> 外文期刊>Psychosomatic Medicine: Journal of the American Psychosomatic Society >Serum cholesterol and cognitive performance in the Framingham Heart Study.
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Serum cholesterol and cognitive performance in the Framingham Heart Study.

机译：弗雷明汉心脏研究的血清胆固醇和认知能力。

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OBJECTIVE: The objective of this study was to examine the relationship between total cholesterol (TC) and cognitive performance within the context of the Framingham Heart Study, a large, community-based, prospective investigation of cardiovascular risk factors. METHODS: Participants were 789 men and 1105 women from the Framingham Heart Study original cohort who were free of dementia and stroke and who received biennial TC determinations over a 16- to 18-year surveillance period. Cognitive tests were administered 4 to 6 years subsequent to the surveillance period and consisted of measures of learning, memory, attention/concentration, abstract reasoning, concept formation, and organizational abilities. Statistical models were adjusted for multiple demographic and biological covariates. RESULTS: There was a significant positive linear association between TC and measures of verbal fluency, attention/concentration, abstract reasoning, and a composite score measuring multiple cognitive domains. Performance levels for three clinically defined groups were examined. Participants with "desirable" TC levels (<200 mg/dL) performed less well than participants with borderline-high TC levels (200-239 mg/dL) and participants with high TC levels (there exists 240 mg/dL). CONCLUSIONS: Lower naturally occurring TC levels are associated with poorer performance on cognitive measures, which place high demands on abstract reasoning, attention/concentration, word fluency, and executive functioning.
机译：目的：本研究的目的是在弗雷明汉心脏研究（Framingham Heart Study）的背景下研究总胆固醇（TC）与认知能力之间的关系，该研究是一项基于社区的大型心血管风险因素前瞻性研究。方法：参加者为Framingham心脏研究原始队列的789名男性和1105名女性，他们无痴呆和中风，并且在16至18年的监测期内接受了两年一次的TC测定。监视期后的4至6年进行认知测试，包括学习，记忆，注意力/集中度，抽象推理，概念形成和组织能力的测量。统计模型针对多个人口和生物协变量进行了调整。结果：TC与口语流利度，注意力/集中度，抽象推理和测量多个认知领域的综合评分之间存在显着的正线性关联。检查了三个临床定义组的表现水平。 TC水平“低于理想水平”（<200 mg / dL）的参与者的表现低于TC边界水平较高的参与者（200-239 mg / dL）和TC水平高的参与者（存在240 mg / dL）。结论：较低的自然发生的TC水平与认知措施的表现较差有关，这对抽象推理，注意力/注意力，单词流利度和执行功能提出了很高的要求。

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