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首页> 外文期刊>Psychosomatic Medicine: Journal of the American Psychosomatic Society >Lung function and cognitive ability in a longitudinal birth cohort study.
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Lung function and cognitive ability in a longitudinal birth cohort study.

机译：纵向出生队列研究中的肺功能和认知能力。

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OBJECTIVE: The objective of this study was to examine the association between forced expiratory volume in 1 second (FEV1) and cognitive ability in midlife in the normal population. METHODS: Multiple regression was used to test associations between FEV1 and cognitive function in 1778 men and women in the MRC National Survey of Health and Development, also known as the British 1946 birth cohort. Analyses were adjusted for sex, body size (birth weight, adult height, weight, and chest circumference), socioeconomic status, lifetime smoking, and a range of health indicators, including early respiratory vulnerability (infant lower respiratory infection, childhood asthma, and exposure to atmospheric pollution). RESULTS: FEV1 at 43 years was associated with slower psychomotor speed (peg placement) at the same age and with slower decline in psychomotor speed (letter search speed) from 43 to 53 years, independently of the previously mentioned potential confounders. These independent associations were not observed, however, for adult verbal ability, verbal memory, or rate of decline in memory, which were significantly explained by socioeconomic status and adolescent cognitive ability. In a subsequent analysis, adolescent cognition was positively associated with FEV1, although not with rate of decline in FEV1 from 43 to 53 years, again independently of the previously mentioned confounders. CONCLUSIONS: Cognitive function and FEV1 are positively associated across the life course. One possible explanation lies in the parallel action of endocrine, autonomic, and motor control systems on respiration and higher mental function. Because respiration and mental function are both associated with functional capacity and survival, this is a matter of potential clinical significance.
机译：目的：本研究的目的是研究正常人群中1秒强迫呼气量（FEV1）与中年认知能力之间的关系。方法：在MRC国家健康与发展全国调查（也称为英国1946年出生队列）中，使用多元回归测试了1778名男女中FEV1与认知功能之间的关联。对性别，体重（出生体重，成人身高，体重和胸围），社会经济状况，终身吸烟以及一系列健康指标进行了分析调整，包括早期呼吸道脆弱性（婴儿下呼吸道感染，儿童哮喘和暴露）大气污染）。结果：与先前提到的潜在混杂因素无关，在相同年龄的43岁时FEV1与较慢的心理运动速度（钉子放置）相关，并且与较慢的心理运动速度（字母搜索速度）从43岁下降至53岁有关。但是，对于成年人的口头表达能力，口头记忆或记忆减退率，没有观察到这些独立的联系，这在社会经济地位和青少年认知能力方面得到了明显的解释。在随后的分析中，青春期认知与FEV1呈正相关，尽管与FEV1从43岁下降至53岁的速率没有关系，这再次与先前提到的混杂因素无关。结论：认知功能和FEV1在整个生命过程中呈正相关。一种可能的解释是内分泌，自主和运动控制系统对呼吸和更高的心理功能的平行作用。因为呼吸和心理功能都与功能能力和生存能力相关，所以这具有潜在的临床意义。

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