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首页> 外文期刊>Psychosomatic Medicine: Journal of the American Psychosomatic Society >Perceived psychologic stress and colorectal cancer mortality: findings from the Japan Collaborative Cohort Study.
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Perceived psychologic stress and colorectal cancer mortality: findings from the Japan Collaborative Cohort Study.

机译：知觉到的心理压力和结肠直肠癌的死亡率：来自日本合作研究的发现。

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OBJECTIVE: The purpose of this research was to examine the relationship between perceived psychologic stress and colorectal cancer mortality in a prospective large-scale study. METHODS: Between the years 1988 and 1990, 32,153 men and 45,854 women aged 40 to 79 years were enrolled. Participants completed a self-administered questionnaire that addressed demographic, lifestyle, and psychosocial characteristics. Subjects were subsequently followed for mortality until the end of 1999. Perceived psychologic stress was assessed using the question "Do you feel stress during your daily life?" The 4 possible responses, ranging from "little or none" (1) to "extreme" (4), were dichotomized as low (1 or 2) or high (3 or 4) stress. Relative risks (RRs) with 95% confidence intervals (CIs) for colon and rectal cancer according to the perceived level of stress were estimated using Cox's proportional hazard model. RESULTS: During the follow-up period (average, 9.6 years), 193 colon cancer deaths (96 men and 97 women) and 127 rectal cancer deaths (88 men and 39 women) were confirmed within the study group. Women who reported high stress had a 1.64-fold higher risk of colon cancer mortality (multivariate-adjusted RR, 1.64; 95% CI, 1.01-2.66) compared with those reporting low stress. There was no significant association between perceived stress and female rectal cancer or male colon and rectal cancer mortality. CONCLUSIONS: Perceived psychologic stress was weakly associated with increased mortality from colon cancer in women. No positive or inverse association was found in men. Further studies are needed to confirm our results.
机译：目的：本研究的目的是在一项前瞻性大规模研究中检验感知到的心理压力与结直肠癌死亡率之间的关系。方法：在1988年至1990年之间，招收了40岁至79岁的32153名男性和45854名女性。参与者完成了一份自我管理的问卷，该问卷针对人口，生活方式和社会心理特征。随后随访受试者的死亡率，直至1999年底。使用“您在日常生活中是否感到压力？”这一问题评估了感知的心理压力。从“很小或没有”（1）到“极端”（4）的4种可能的响应被分为低（1或2）或高（3或4）应力。使用Cox比例风险模型估算了根据感知的压力水平，结肠癌和直肠癌的相对风险（RRs）为95％置信区间（CIs）。结果：在随访期间（平均9.6年），在研究组中确认了193例结肠癌死亡（96例男性和97例女性）和127例直肠癌死亡（88例男性和39例女性）。与低压力女性相比，高压力女性罹患结肠癌的风险高1.64倍（多因素调整后RR，1.64; 95％CI，1.01-2.66）。知觉压力与女性直肠癌或男性结肠癌和直肠癌死亡率之间没有显着相关性。结论：知觉到的心理压力与女性结肠癌死亡率增加的相关性较弱。在男性中未发现正向或反向关联。需要进一步研究以确认我们的结果。

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