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首页> 外文期刊>Psychosomatic Medicine: Journal of the American Psychosomatic Society >Gender differences in associations of C-reactive protein with atherosclerotic risk factors and psychosocial characteristics in Japanese civil servants.
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Gender differences in associations of C-reactive protein with atherosclerotic risk factors and psychosocial characteristics in Japanese civil servants.

机译：日本公务员中C反应蛋白与动脉粥样硬化危险因素和社会心理特征之间的性别差异。

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OBJECTIVE: Several prospective studies have demonstrated a direct association between high-sensitivity C-reactive protein (hsCRP) and the risks of developing cardiovascular disease. A strong sense of coherence (SOC) has also been associated with a reduced risk of cardiovascular mortality, but the underlying pathophysiologic mechanism remains unclear. We have evaluated the relationship of serum CRP and SOC and assessed the association of atherosclerotic risk factors with CRP in male and female subjects. METHODS: Data were collected in 2003 and 2004 cross-sectionally from the two phases of a longitudinal study. Atherosclerotic risk factors were evaluated along with psychosocial characteristics for 1,339 apparently healthy civil servants (748 women and 591 men) aged 20 to 60 years. The Japanese version of the SOC-13 was used in the study. RESULTS: After controlling for traditional atherosclerotic risk factors, SOC was inversely associated with hsCRP levels only in men. Among the atherosclerotic risk factors, body mass index and high-density lipoprotein cholesterol had the strongest associations with hsCRP in both sexes. Mean arterial pressure and blood glucose were positively correlated with hsCRP in men, and serum triglyceride levels positively correlated with hsCRP in women. CONCLUSION: The findings suggested that a higher SOC might be associated with lower serum CRP levels in men. Also, the association of traditional atherosclerotic risk factors with CRP was not equal in men and women.
机译：目的：多项前瞻性研究表明，高敏C反应蛋白（hsCRP）与患心血管疾病的风险之间存在直接关联。强烈的连贯感（SOC）也与降低心血管疾病死亡率的风险有关，但潜在的病理生理机制仍不清楚。我们评估了男性和女性受试者血清CRP和SOC的关系，并评估了动脉粥样硬化危险因素与CRP的关联。方法：从纵向研究的两个阶段横断面收集了2003年和2004年的数据。对年龄在20至60岁的1,339名看上去健康的公务员（748名女性和591名男性）的动脉粥样硬化危险因素以及心理社会特征进行了评估。这项研究使用了日文版的SOC-13。结果：在控制了传统的动脉粥样硬化危险因素后，SOC仅与男性的hsCRP水平呈负相关。在动脉粥样硬化的危险因素中，体重指数和高密度脂蛋白胆固醇与hsCRP的关联最强。男性的平均动脉压和血糖与hsCRP呈正相关，女性的血清甘油三酸酯水平与hsCRP呈正相关。结论：研究结果提示较高的SOC可能与男性血清CRP水平降低有关。而且，传统的动脉粥样硬化危险因素与CRP的关联在男人和女人中并不相等。

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