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首页> 外文期刊>Psychosomatic Medicine: Journal of the American Psychosomatic Society >Opioid analgesia in persons at risk for hypertension.
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Opioid analgesia in persons at risk for hypertension.

机译：阿片类镇痛有高血压风险。

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OBJECTIVE: Acute pain sensitivity is reduced in clinical hypertension, but the precise relationship between pain perception and altered blood pressure control is not well-characterized. A negative correlation between resting blood pressure and pain sensitivity is observed throughout the normotensive range, suggesting links between basic mechanisms of blood pressure control and pain regulation. The opioid peptides are important endogenous analgesic mechanisms, but their role in the hypoalgesia of blood pressure elevations has not been well-established. The current study sought to examine the effects of endogenous opioids on blood pressure-associated hypoalgesia in young adults at risk for hypertension development. METHODS: The effects of the opioid receptor antagonist, naltrexone, on cold pressor pain sensitivity were assessed in young adult men (n = 49) and women (n = 76) with mildly elevated casual blood pressure. RESULTS: Results indicate interactions between hypertension risk and the effects of opioid blockade on pain sensitivity. CONCLUSIONS: These findings suggest exaggerated opioid analgesia in persons at enhanced risk for hypertension and point to important links between altered neuropeptide regulation of pain and altered blood pressure control mechanisms in the early stages of hypertension.
机译：目的：急性高血压敏感性在临床高血压中降低，但疼痛知觉与血压控制改变之间的确切关系尚不十分清楚。在正常血压范围内，静息血压与疼痛敏感性之间呈负相关，这表明血压控制和疼痛调节的基本机制之间存在联系。阿片样肽是重要的内源性镇痛机制，但是它们在血压升高的痛觉过敏中的作用尚未得到充分确立。当前的研究试图检查内源性阿片类药物对有高血压危险的年轻人的血压相关性痛觉过敏的影响。方法：在年轻的成年男性（n = 49）和女性（n = 76）中，偶然血压轻度升高，评估了阿片受体拮抗剂纳曲酮对冷压痛敏感性的影响。结果：结果表明，高血压风险与阿片类药物阻滞剂对疼痛敏感性的相互作用。结论：这些发现表明，高血压风险增加的人使用了阿片类药物进行过大的镇痛，并指出在高血压早期，神经肽对疼痛的调节作用改变与血压控制机制改变之间存在重要联系。

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