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首页> 外文期刊>Psychosomatic Medicine: Journal of the American Psychosomatic Society >Temporal factors alter effects of social housing conditions on responses to chemotherapy and hormone levels in a Shionogi mammary tumor model.
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Temporal factors alter effects of social housing conditions on responses to chemotherapy and hormone levels in a Shionogi mammary tumor model.

机译：时间因素会改变社交环境对Shionogi乳腺肿瘤模型中化学疗法和激素水平的影响。

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Objective: To identify possible hormonal factors involved in the differential responses to chemotherapy observed in our tumor model, we investigated if the timing among tumor cell injection, rehousing, and chemotherapy administration differentially affects levels of corticosterone (CORT), growth hormone (GH), and testosterone and tumor and host responses to chemotherapy. Methods: Mice were reared either individually (I) or in groups (G). At 2 to 4 months, mice were injected with tumor cells and retained in their original housing conditions or rehoused into different experimental groups (GG, IG, II, GI) either immediately (experiment 1) or 14 days later (experiment 2); chemotherapy was administered when tumors weighed approximately 0.8 g. Results: In experiment 1, IG and GG mice had better responses to chemotherapy than GI mice. Chemotherapy increased CORT levels in II mice and decreased GH levels in GI mice compared with those of their drug vehicle-treated counterparts. Under the temporal conditions ofexperiment 2, IG and GG mice lost the advantage seen in experiment 1 in terms of tumor and host responses to chemotherapy. Before chemotherapy administration, CORT levels in IG mice and GH levels in GI mice were higher than those in mice in all other housing conditions. At 1 day after chemotherapy, CORT levels were higher for chemotherapy-treated than for drug vehicle-treated IG mice, and at 5 days post chemotherapy, GH levels were higher in GI than in IG mice. Conclusions: Temporal relationships among tumor cell injection, rehousing, and chemotherapy administration critically influence responses to chemotherapy; these effects may be mediated, in part, by alterations in hormone levels.
机译：目的：为了确定在我们的肿瘤模型中观察到的对化学疗法的不同反应中可能涉及的激素因素，我们调查了肿瘤细胞注射，重新安置和化学疗法给药之间的时间差异是否会影响皮质酮（CORT），生长激素（GH），以及睾丸激素和肿瘤以及宿主对化疗的反应。方法：单独（I）或分组（G）饲养小鼠。在2到4个月后，立即（实验1）或14天（实验2）给小鼠注射肿瘤细胞，并使其保持原始状态，或重新安置在不同的实验组（GG，IG，II，GI）中;当肿瘤重约0.8 g时进行化学疗法。结果：在实验1中，IG和GG小鼠对化疗的反应优于GI小鼠。与用药物媒介物治疗的同伴相比，化学疗法增加了II小鼠的CORT水平，并降低了GI小鼠的GH水平。在实验2的时间条件下，就肿瘤和宿主对化学疗法的反应而言，IG和GG小鼠失去了实验1的优势。在化疗之前，IG小鼠的CORT水平和GI小鼠的GH水平均高于其他所有居住条件下的小鼠。化疗后1天，化疗后的CORT水平高于药物媒介物治疗的IG小鼠，化疗后5天，GI的GH水平高于IG小鼠。结论：肿瘤细胞注射，安置和化疗之间的时间关系严重影响对化疗的反应。这些作用可能部分地由激素水平的改变介导。

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