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首页> 外文期刊>Psychosomatic Medicine: Journal of the American Psychosomatic Society >Plasma endothelin-1 release during acute stress: role of ethnicity and sex.
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Plasma endothelin-1 release during acute stress: role of ethnicity and sex.

机译：急性应激期间血浆内皮素-1的释放：种族和性别的作用。

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OBJECTIVES: The purposes of this study were to examine possible ethnic and sex differences in plasma ET-1 levels at rest and in response to acute stress and to examine relationships between ET-1 and vasoconstrictive-mediated BP reactivity to stress. METHODS: Two hundred twenty-two adolescents (mean age = 18.5 +/- 2.8 years; 130 [70 males] EAs and 92 [48 males] AAs) completed two stressors (video game, forehead cold). Hemodynamic measures and blood samples were collected at catheter insertion and before and immediately after the two stressors, separated by 20-minute rest periods. RESULTS: AAs and males exhibited higher levels of SBP and DBP and of TPRI and ET-1 at each sampling point compared with EAs and females, respectively (p values <.001). AAs and males exhibited greater increases in SBP, TPRI, and ET-1 in response to each stressor (p values <.05). Intraindividual correlations between ET-1 and hemodynamic parameters revealed that most individuals exhibited a positive association between ET-1, BP, and TPRI. However, some individuals exhibited a negative association between ET-1 and the above-mentioned hemodynamics, suggesting a compensatory vasodilation mechanism. CONCLUSION: The findings demonstrate significant sex and ethnicity differences in stress-induced vasoconstrictive peptide release and support the hypothesis that these differences may be important in explaining the ethnicity and sex differences in the prevalence of cardiovascular disease.
机译：目的：本研究的目的是检查静息时和对急性应激反应血浆ET-1水平可能存在的种族和性别差异，并探讨ET-1与血管收缩介导的血压反应对应激的关系。方法：222名青少年（平均年龄= 18.5 +/- 2.8岁; 130位[70男性] EA和92位[48男性] AA）完成了两个压力源（视频游戏，前额感冒）。在插入导管时以及在两个压力源之前和之后立即收集血流动力学指标和血液样本，相隔20分钟的休息时间。结果：与EAs和女性相比，AA和男性在每个采样点分别表现出较高的SBP和DBP以及TPRI和ET-1水平（p值<.001）。 AA和雄性对每个应激源的SBP，TPRI和ET-1表现出更大的增加（p值<.05）。 ET-1与血液动力学参数之间的个体内相关性表明，大多数个体在ET-1，BP和TPRI之间表现出正相关。但是，有些人在ET-1与上述血液动力学之间表现出负相关关系，这表明存在代偿性血管舒张机制。结论：研究结果表明，在压力诱导的血管收缩肽释放过程中，性别存在明显差异，并支持以下假设：这些差异可能对解释心血管疾病患病的种族和性别差异具有重要意义。

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