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首页> 外文期刊>Psychosomatic Medicine: Journal of the American Psychosomatic Society >Pyrogenic cytokines did not mediate a stress interview-induced hyperthermic response in a patient with psychogenic fever: a case report.
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Pyrogenic cytokines did not mediate a stress interview-induced hyperthermic response in a patient with psychogenic fever: a case report.

机译：热原细胞因子未介导精神病患者的面试压力诱发的高温反应：一例病例报告。

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OBJECTIVE: To investigate if pyrogenic cytokines mediated psychological stress-induced hyperthermic response in a patient with psychogenic fever. Despite many case reports on psychogenic fever, the mechanism responsible for how psychological stress increases core body temperature (Tc) in humans is not yet known. CASE PRESENTATION: A 13-year-old girl with fever (>38 degrees C) of unknown causes was referred to our department because psychogenic fever was suspected. To determine if the fever was actually induced by psychological stress, we conducted a 60-minute stress interview. Her baseline oral temperature was 36.60 degrees C and it began to increase immediately after commencement of the interview, reaching a maximum of 37.42 degrees C 20 minutes after the end of the interview. The plasma level of prostaglandin E(2) and the serum interleukin-6 level were increased 90 minutes after the interview. Serum levels of interleukin-1alpha, interleukin-1beta, and macrophage inflammatory protein-1alpha were all less than their minimum detectable level throughout the observation period. We also measured the patient's thermal preference by immersing her hands in warm (40 degrees C) and cold (20 degrees C) water. Her preference changed from cold to warm only during the increasing phase of oral temperature. CONCLUSIONS: This case report shows that a stress interview actually increased Tc in a patient with psychogenic fever. This study suggests that, although pyrogenic cytokines are not involved, the stress interview-induced increase in Tc was an active hyperthermia under the control of the brain, as is infection-induced fever.
机译：目的：探讨热原性细胞因子是否介导心理性发烧患者的心理应激诱导的高温反应。尽管有许多关于精神病热的病例报道，但尚不清楚导致心理压力如何增加人的核心体温（Tc）的机制。病例介绍：一名原因不明的发烧（> 38摄氏度）的13岁女孩被转诊到我科，因为怀疑是精神病性发烧。为了确定发烧是否实际上是由心理压力引起的，我们进行了60分钟的压力访谈。她的基线口腔温度为36.60摄氏度，在访谈开始后立即开始升高，在访谈结束后20分钟达到最高37.42摄氏度。访谈后90分钟，血浆前列腺素E（2）水平和血清白介素6水平升高。在整个观察期间，血清白介素-1α，白介素-1β和巨噬细胞炎性蛋白-1α的水平均低于其最低可检测水平。我们还通过将患者的手浸入温水（40摄氏度）和冷水（20摄氏度）中来测量患者的热偏好。她的偏爱仅在口腔温度升高阶段才从冷变热。结论：该病例报告表明，精神病患者的压力访谈实际上增加了Tc。这项研究表明，尽管不涉及热原性细胞因子，但压力面试诱发的Tc升高是一种在大脑控制下的活动性高热，感染引起的发烧也是如此。

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