• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Psychosomatic Medicine: Journal of the American Psychosomatic Society >Neural correlates of deficits in pain-related affective meaning construction in patients with chronic pain disorder
【24h】

Neural correlates of deficits in pain-related affective meaning construction in patients with chronic pain disorder

机译：慢性疼痛疾病患者疼痛相关情感意义建构缺陷的神经相关

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

OBJECTIVE: Psychological and neural mechanisms of the affective dimension of pain are known to be disturbed in patients with chronic pain disorder. The aim of this functional magnetic resonance imaging study was to assess the neurofunctional and behavioral measures underlying the ability to construct pain-related affective meaning in a painful situation by comparing 21 clinically and psychometrically well-characterized patients with persistent non-nociceptive somatoform pain with 19 healthy controls. METHODS: The functional magnetic resonance imaging task involved viewing pictures depicting human hands and feet in different painful and nonpainful situations. Participants were asked to estimate the perceived pain intensity. These data were correlated with behavioral measures of depression, alexithymia, and general cognitive and emotional empathy. RESULTS: In a hypothesis-driven region-of-interest analysis, the healthy control group exhibited greater activation of the left perigenual anterior cingulate cortex than patients with pain (Montreal Neurological Institute coordinates (x y z) = -8 38 0; cluster extent = 54 voxels; T = 4.28; p = .006 corrected for multiple comparisons at cluster level). No group differences in the activation of the anterior insular cortex were found. Scores on self-assessment instruments (Beck Depression Inventory I, Interpersonal Reactivity Index, and 20-item Toronto Alexithymia Scale) did not influence neuroimaging results. CONCLUSIONS: Our results suggest that patients with chronic medically unexplained pain have an altered neural pain perception process owing to decreased activation of empathetic-affective networks, which we interpret as a deficit in pain-related affective meaning construction. These findings may lead to a more specific and detailed neurobiological understanding of the clinical impression of disturbed affect in patients with chronic pain disorder.
机译：目的：已知慢性疼痛障碍患者的情感影响范围的心理和神经机制受到干扰。这项功能性磁共振成像研究的目的是，通过比较21例临床和心理特征良好的持续性非伤害性躯体形式疼痛患者与19例持续性非伤害性躯体形式疼痛的患者，评估在疼痛情况下构建与疼痛相关的情感含义的能力的神经功能和行为测量健康对照。方法：功能磁共振成像任务涉及查看描绘在不同疼痛和非疼痛情况下人的手和脚的图像。要求参与者估计感觉到的疼痛强度。这些数据与抑郁，行为障碍和一般的认知和情感移情的行为指标相关。结果：在假设驱动的关注区域分析中，健康对照组的疼痛周围患者左扣带状前扣带回皮层的激活程度高于疼痛患者（蒙特利尔神经研究所坐标（xyz）= -8 38 0;簇范围= 54体素; T = 4.28; p = 0.006，用于在群集级别进行多次比较。未发现前岛突皮层激活的组差异。自我评估工具的评分（贝克抑郁量表I，人际反应性指数和20个项的多伦多Alexithymia量表）不影响神经影像学结果。结论：我们的结果表明，由于移情-情感网络的激活减少，患有慢性医学上无法解释的疼痛的患者神经痛的感知过程发生了改变，我们将其解释为与疼痛相关的情感意义建构的缺陷。这些发现可能会导致对慢性疼痛疾病患者情感障碍的临床印象更具体和详细的​​神经生物学理解。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号