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首页> 外文期刊>Psychosomatic Medicine: Journal of the American Psychosomatic Society >Prenatal stress and cerebral palsy: a nationwide cohort study in Denmark.
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Prenatal stress and cerebral palsy: a nationwide cohort study in Denmark.

机译：产前压力和脑瘫：丹麦的一项全国队列研究。

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OBJECTIVES: Exposure to prenatal stress may affect neurodevelopment of the fetus, but whether this exposure increases the risk of cerebral palsy (CP) later in life is unknown. We aimed to examine the association between maternal bereavement during the prenatal time period and CP in childhood. METHODS: We conducted a nationwide cohort study by linking information from nationwide registers. All 1,501,894 singletons born in Denmark from 1979 to 2004 were followed up from birth to the end of 2006. We identified 39,601 children whose mothers lost a close relative (child, spouse, parent, sibling) during pregnancy or up to 1 year before pregnancy and they were classified as the exposed group. The outcome of interest was the diagnosis of CP as registered in the National Hospital Register. We used Cox Regression to estimate the hazard ratios (HRs). RESULTS: Exposure to maternal bereavement after the loss of a child during the prenatal period was associated with an increased risk of CP among children born preterm without intrauterine growth retardation (HR 2.26, 95% CI, 1.09-3.79) and among children born at term with intrauterine growth retardation (HR 2.01, 95% CI, 1.04-3.89). Prenatal stress after maternal bereavement by loss of other relatives was not associated with an increased risk of CP. CONCLUSIONS: Our data suggest that extremely severe stress in prenatal life could increase the susceptibility for CP among children born preterm or with impaired fetal growth.
机译：目的：暴露于产前压力可能会影响胎儿的神经发育，但是这种暴露是否会增加生命后期患脑瘫的风险尚不清楚。我们旨在研究产前时期的母亲丧亲与儿童期CP的关系。方法：我们通过链接来自全国登记册的信息进行了全国队列研究。从出生到2006年底，对丹麦在1979年至2004年出生的所有1,501,894个单身人士进行了随访。我们确定了39,601名孩子的母亲在怀孕期间或怀孕前长达一年的时间失去了近亲（孩子，配偶，父母，兄弟姐妹），并且他们被归类为暴露人群。感兴趣的结果是在国家医院注册簿中对CP的诊断。我们使用Cox回归来估计危险比（HRs）。结果：在产前期间失去孩子后，遭受母体丧亲的人与没有宫内发育迟缓的早产儿（HR 2.26，95％CI，1.09-3.79）和足月儿中的CP风险增加相关宫内发育迟缓（HR 2.01，95％CI，1.04-3.89）。失去其他亲戚造成的母亲丧亲后的产前压力与患CP的风险增加无关。结论：我们的数据表明，产前生活中极度紧张的压力可能会增加早产或胎儿生长受损儿童的CP易感性。

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