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首页> 外文期刊>Psychosomatic Medicine: Journal of the American Psychosomatic Society >Hostility and minimal model of glucose kinetics in African American women.
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Hostility and minimal model of glucose kinetics in African American women.

机译：非洲裔美国女性的葡萄糖动力学的敌意和极简模型。

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OBJECTIVE: To explore the underlying physiology of hostility (HOST) and to test the hypothesis that HOST has a greater impact on fasting glucose in African American (AA) women than it does on AA men or white men or women, using an intravenous glucose tolerance test (IVGTT) and the minimal model of glucose kinetics. METHODS: A total of 115 healthy subjects selected for high or low scores on the 27 item Cook Medley HOST Scale underwent an IVGTT. Fasting nonesterified fatty acids (NEFA) levels were measured before the IVGTT. Catecholamine levels were measured 10 minutes into the IVGTT. RESULTS: Moderation by group (AA women versus others) of HOST was found for glucose effectiveness (Sg, p = .02), acute insulin response (AIRg, p = .02), and disposition index (DI, p = .02). AA women showed a negative association between HOST and both Sg (beta = -0.45, p = .04) and DI (beta = -0.49, p = .02), controlling for age and body mass index. HOST was also associated with changes in epinephrine (beta = 0.39, p = .05) and fasting NEFA (beta = 0.44, p = .02) in the AA women. Controlling for fasting NEFA reduced the effect of HOST on both Sg and DI. CONCLUSIONS: This study shows that HOST is related to decreased DI, a measure of pancreatic compensation for increased insulin resistance as well as decreased Sg, a measure of noninsulin-mediated glucose transport compared in AA women. These effects are partly mediated by the relationship of HOST to fasting NEFA.
机译：目的：通过静脉内葡萄糖耐量试验，探讨敌对（HOST）的潜在生理学并检验以下假设：HOST对非裔美国人（AA）妇女的空腹血糖影响大于对AA男性或白人男性或女性的禁食葡萄糖影响测试（IVGTT）和葡萄糖动力学的最小模型。方法：对共计27项Cook Medley HOST量表的高分或低分选择的115名健康受试者进行了IVGTT。在IVGTT前测量空腹非酯化脂肪酸（NEFA）的水平。在IVGTT中10分钟测量儿茶酚胺水平。结果：HOST的组别（AA妇女相对于其他人）在葡萄糖有效性（Sg，p = .02），急性胰岛素反应（AIRg，p = .02）和处置指数（DI，p = .02）方面有所发现。机管局妇女显示出HOST与Sg（β= -0.45，p = .04）和DI（β= -0.49，p = .02）之间呈负相关，从而控制了年龄和体重指数。在AA妇女中，HOST也与肾上腺素的变化（β= 0.39，p = .05）和禁食NEFA（β= 0.44，p = .02）有关。禁食NEFA的控制减少了HOST对Sg和DI的影响。结论：这项研究表明，与AA妇女相比，HOST与DI降低有关，DI降低是衡量胰岛素抵抗增加的胰腺补偿指标，而Sg降低是衡量非胰岛素介导的葡萄糖转运的指标。这些影响部分是由HOST与禁食NEFA的关系介导的。

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