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The effect of pegylated interferon-alpha2b and ribavirin on posttraumatic stress disorder symptoms.

机译：聚乙二醇化干扰素-α2b和利巴韦林对创伤后应激障碍症状的影响。

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BACKGROUND: Patients with chronic psychiatric diagnoses have a prevalence of chronic hepatitis C (HCV) approximately 11 times higher than the general American population. Posttraumatic stress disorder (PTSD) is particularly common among HCV patients. OBJECTIVE: The authors describe the effect of treatment with pegylated-interferon-alpha(2b) (IFN) and ribavirin for patients with HCV on their posttraumatic stress disorder (PTSD) symptoms. METHOD: Sixteen patients with HCV and combat-related PTSD were followed for 24 weeks and assessed with self-report measures of PTSD, hostility, and depression. RESULTS: Depression and Resentment scores significantly increased in five patients treated with IFN and ribavirin, but no significant differences were found in PTSD scores when compared with 11 control patients. CONCLUSION: The results suggest that patients with PTSD and HCV can be safely treated with anti-viral therapies when they are given appropriate psychiatric care.
机译：背景：患有慢性精神病诊断的患者的慢性丙型肝炎（HCV）患病率比普通美国人高约11倍。创伤后应激障碍（PTSD）在HCV患者中尤为常见。目的：作者描述了聚乙二醇干扰素-α（2b）（IFN）和利巴韦林对HCV患者的创伤后应激障碍（PTSD）症状的治疗效果。方法：对16例HCV和与战斗有关的PTSD的患者进行了为期24周的随访，并通过PTSD的自我报告，敌意和抑郁进行了评估。结果：5例接受IFN和利巴韦林治疗的患者的抑郁和怨恨得分显着提高，但与11例对照患者相比，PTSD得分无明显差异。结论：结果表明，PTSD和HCV患者在接受适当的精神病治疗后可以安全地接受抗病毒治疗。

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