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首页> 外文期刊>Psychosomatics >Pretransplant psychiatric and substance use comorbidity in patients with cholangiocarcinoma who received a liver transplant.
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Pretransplant psychiatric and substance use comorbidity in patients with cholangiocarcinoma who received a liver transplant.

机译：接受肝移植的胆管癌患者移植前的精神病和药物使用合并症。

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Psychopathology has been commonly observed in liver transplant candidates, and up to 40% have comorbid psychiatric disorders. This illness burden may negatively impact quality of life and transplant outcome. Liver transplantation for cholangiocarcinoma remains uncommon due to the complex treatment protocol. We assessed for pretransplant psychopathology and substance use disorders in liver transplant recipients with cholangiocarcinoma to better characterize this patient group.We retrospectively reviewed the records of 143 liver transplant recipients who completed pretransplant psychological screening with the PAS, BDI-FS, BSI-18, and the SAAST between 2000 and 2004. The majority completed an evaluation by a transplant psychiatrist. Rates of pretransplant psychiatric and substance use symptoms and disorders were compared between 26 patients with cholangiocarcinoma and 117 other liver recipients using χ(2) or Fisher's exact tests.Of the total cohort, 35% had a pretransplant psychiatric diagnosis, 35% had a substance use disorder, and 43% were current or former smokers. The cholangiocarcinoma cohort had significantly lower scores on the PAS, BDI-FS, and the BSI-18. On interview, the cholangiocarcinoma group was less likely to have an alcohol use disorder (P = 0.03) or any substance use disorder (P = 0.04), but the two groups did not differ significantly in the likelihood of having a psychiatric disorder or smoking history.This study suggests that patients with cholangiocarcinoma have lower rates of alcohol and drug use disorders than other liver transplant recipients. They do not differ in rates of psychiatric disorders or smoking. Psychosocial assessment and support are recommended throughout the transplant process.
机译：在肝移植候选者中通常观察到精神病理学，并且高达40％患有合并性精神病。这种疾病负担可能会对生活质量和移植结果产生负面影响。由于复杂的治疗方案，肝移植治疗胆管癌仍然不常见。我们评估了胆管癌肝移植受者的移植前心理病理学和物质使用障碍，以更好地表征该患者群。我们回顾性回顾了143名完成PAS，BDI-FS，BSI-18和BSI的肝移植受者的记录。在2000年至2004年之间进行了SAAST评估。大多数人完成了移植精神科医生的评估。使用χ（2）或Fisher精确检验比较了26位胆管癌患者和117位其他肝接受者的移植前精神病和药物使用症状和疾病发生率，在总队列中，有35％接受了移植前精神病学诊断，35％接受了物质使用障碍，其中43％为现在或以前的吸烟者。胆管癌队列在PAS，BDI-FS和BSI-18上的得分明显较低。访谈中，胆管癌组不太可能有饮酒障碍（P = 0.03）或任何物质使用障碍（P = 0.04），但两组在精神病或吸烟史方面的可能性没有显着差异这项研究表明，胆管癌患者的酒精和药物滥用疾病发生率低于其他肝移植受者。他们的精神疾病或吸烟率没有差异。建议在整个移植过程中进行社会心理评估和支持。

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